Document Detail

Trazodone for aggression in an adolescent with hydrocephalus.
MedLine Citation:
PMID:  9201759     Owner:  NLM     Status:  MEDLINE    
A case of 19 year old male with hydrocephalus is reported whose aggressive self-injurious behaviors were resistant to conventional pharmacotherapy but successfully treated by trazodone. In addition to the self-injurious behaviors, this patient displayed withdrawal and eating refusal, which initially resulted in his admission to a psychiatric ward. Various conventional treatments with pharmacotherapy (e.g., tricyclic antidepressants, antipsychotics, anxiolytics and anticonvulsants) in combination with psychotherapy and family therapy proved not to be effective for 15 months. Neither was electroconvulsive therapy successful. Administration of trazodone for 5 months after tapering of the above agents improved his aggressive behaviors. A survey of previous cases with organic brain syndromes who had aggressive behaviors and responded well to trazodone revealed that most of the cases were aged individuals and that cases in adolescence are rare.
H Mashiko; H Yokoyama; H Matsumoto; S Niwa
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Psychiatry and clinical neurosciences     Volume:  50     ISSN:  1323-1316     ISO Abbreviation:  Psychiatry Clin. Neurosci.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-08-28     Completed Date:  1997-08-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9513551     Medline TA:  Psychiatry Clin Neurosci     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  133-6     Citation Subset:  IM    
Department of Neuropsychiatry, Fukushima Medical College, Japan.
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MeSH Terms
Aggression / drug effects*
Antipsychotic Agents / therapeutic use
Electroconvulsive Therapy
Family Therapy
Hydrocephalus / complications*,  psychology
Middle Aged
Self-Injurious Behavior / drug therapy*,  therapy
Serotonin Uptake Inhibitors / administration & dosage,  therapeutic use*
Trazodone / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Serotonin Uptake Inhibitors; 19794-93-5/Trazodone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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