| Travelling gradients in interacting morphogen systems. | |
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MedLine Citation:
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PMID: 17363011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Morphogen gradients are well known to play several important roles in development; however the mechanisms underlying the formation and maintenance of these gradients are often not well understood. In this work, we investigate whether the presence of a secondary morphogen can increase the robustness of the primary morphogen gradient to perturbation, thereby providing a more stable mechanism for development. We base our model around the interactions of Fibroblast Growth Factor 8 and retinoic acid, which have been shown to act as morphogens in many developmental systems. In particular, we investigate the formation of opposing gradients of these morphogens along the antero-posterior axis of vertebrate embryos, thereby controlling temporal and spatial aspects of axis segmentation and neuronal differentiation. |
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Authors:
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R E Baker; P K Maini |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-08 |
Journal Detail:
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Title: Mathematical biosciences Volume: 209 ISSN: 0025-5564 ISO Abbreviation: Math Biosci Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-11-08 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0103146 Medline TA: Math Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 30-50 Citation Subset: IM |
Affiliation:
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Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24-29 St. Giles', Oxford OX1 3LB, UK. ruth.baker@maths.ox.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Embryonic Development / physiology* Fibroblast Growth Factor 8 / physiology* Models, Biological* Morphogenesis / physiology* Numerical Analysis, Computer-Assisted Tretinoin / physiology* Vertebrates / embryology* |
| Chemical | |
Reg. No./Substance:
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148997-75-5/Fibroblast Growth Factor 8; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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