Document Detail

Travelling gradients in interacting morphogen systems.
MedLine Citation:
PMID:  17363011     Owner:  NLM     Status:  MEDLINE    
Morphogen gradients are well known to play several important roles in development; however the mechanisms underlying the formation and maintenance of these gradients are often not well understood. In this work, we investigate whether the presence of a secondary morphogen can increase the robustness of the primary morphogen gradient to perturbation, thereby providing a more stable mechanism for development. We base our model around the interactions of Fibroblast Growth Factor 8 and retinoic acid, which have been shown to act as morphogens in many developmental systems. In particular, we investigate the formation of opposing gradients of these morphogens along the antero-posterior axis of vertebrate embryos, thereby controlling temporal and spatial aspects of axis segmentation and neuronal differentiation.
R E Baker; P K Maini
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-08
Journal Detail:
Title:  Mathematical biosciences     Volume:  209     ISSN:  0025-5564     ISO Abbreviation:  Math Biosci     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-11-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0103146     Medline TA:  Math Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-50     Citation Subset:  IM    
Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24-29 St. Giles', Oxford OX1 3LB, UK.
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MeSH Terms
Embryonic Development / physiology*
Fibroblast Growth Factor 8 / physiology*
Models, Biological*
Morphogenesis / physiology*
Numerical Analysis, Computer-Assisted
Tretinoin / physiology*
Vertebrates / embryology*
Reg. No./Substance:
148997-75-5/Fibroblast Growth Factor 8; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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