Document Detail

Traumatic thalamic injury demonstrated by diffusion tensor tractography of the spinothalamic pathway.
MedLine Citation:
PMID:  23672449     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study reports on a patient with traumatic brain injury (TBI) with a thalamic lesion in the ventroposterolateral nucleus which was demonstrated by diffusion tensor tractography (DTT) for the spinothalamic tract and its thalamocortical pathway (STP).
METHODS: One patient with TBI and eight normal control subjects were recruited. A 64-year-old woman who had suffered a motor vehicle accident presented with a persisting tingling sensation and pain in her right upper and lower extremities at 3 weeks after onset. The patient showed impaired touch sensation, but normal proprioception. Diffusion tensor imaging was performed at 1 month after onset. Fractional anisotropy (FA) and mean diffusivity were measured using a region of interest method along the STP.
RESULTS: DTT showed normal STP integrities as compared with normal controls. However, the FA values of the left STP at the thalamus were more than 2 SD decreased. The diminished FA value of the left STP in the left thalamus seems to indicate injury of the left ventrolateroposterior nucleus. Central pain and impaired touch sensation of right extremities supports the presence of left STP injury at the ventroposterolateral nucleus in this patient.
CONCLUSION: It is believed that DTT for the STP provides a useful means of detecting thalamic injury in TBI.
Jeong Pyo Seo; Sung Ho Jang
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-05
Journal Detail:
Title:  Brain injury     Volume:  27     ISSN:  1362-301X     ISO Abbreviation:  Brain Inj     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-15     Completed Date:  2013-12-30     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  8710358     Medline TA:  Brain Inj     Country:  England    
Other Details:
Languages:  eng     Pagination:  749-53     Citation Subset:  IM    
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MeSH Terms
Brain Injuries / complications,  physiopathology*
Diffusion Tensor Imaging* / methods
Memory Disorders / diagnosis*,  etiology
Middle Aged
Pain / diagnosis*,  etiology
Personality Disorders / diagnosis*,  etiology
Predictive Value of Tests
Severity of Illness Index
Spinothalamic Tracts / physiopathology
Thalamus / injuries,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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