Document Detail

Trauma profile in egyptian adolescents with first-episode schizophrenia: relation to psychopathology and plasma brain-derived neurotrophic factor.
MedLine Citation:
PMID:  23274291     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT: We aimed to investigate the relation of trauma profile to schizophrenia psychopathology in a sample of Egyptian drug-naïve adolescent patients with first-episode schizophrenia. In addition, a hypothesized mediating effect of brain-derived neurotrophic factor (BDNF) in this relation was formally tested. We assessed 74 eligible outpatients using the Positive and Negative Syndrome Scale (PANSS) for measuring psychopathology. Trauma histories were recorded with the help of the Cumulative Trauma Measure. Serum BDNF levels were estimated by enzyme-linked immunosorbent assay. Total cumulative trauma, personal identity trauma, and survival trauma were found to be the significant predictors for schizophrenia psychopathology. BDNF fully mediated the associations between total cumulative trauma and overall schizophrenia psychopathology. BDNF also mediated the associations between some types of trauma and both PANSS-positive and PANSS-negative symptom factors. We concluded that total cumulative trauma and certain trauma types are linked with schizophrenia psychopathology. BDNF appears to mediate these links.
Mounir H Fawzi; Ibrahim A Kira; Mohab M Fawzi; Hanan E Mohamed; Maggie M Fawzi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nervous and mental disease     Volume:  201     ISSN:  1539-736X     ISO Abbreviation:  J. Nerv. Ment. Dis.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375402     Medline TA:  J Nerv Ment Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  AIM; IM    
*Department of Psychiatry, Faculty of Medicine, Zagazig University, Zagazig, Egypt; †Center for Torture and Trauma Survivors and Center for Cumulative Trauma Studies, Stone Mountain, GA; and ‡Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
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