| Trauma and military applications of blood substitutes. | |
| | |
MedLine Citation:
|
PMID: 8087238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To review potential clinical uses of erythrocyte substitutes in treating military battlefield casualties, with specific emphasis on combat injury rates and wounding patterns, resuscitation doctrine and logistic requirements. METHODS: Review of published medical literature and of unclassified documents from the U.S. Armed Forces Blood Program. RESULTS: Hemorrhage is the leading cause of death on the battlefield. Early intervention, with definitive treatment, could save up to 30% of soldiers who are killed in action or who die of wounds. Hemorrhage control and rapid volume expansion in appropriate casualties are the main priorities in pre-hospital resuscitation of battlefield casualties. The role for oxygen-carrying fluids in the initial management of military injuries is undefined; however, erythrocyte substitutes could reduce the logistic requirements for blood in field hospitals. In recent wars, outdating of stored blood resulted in 60-95% of units being discarded: 60% of 1.3 million units in Vietnam and 95% of 120,000 units in the Persian Gulf War. CONCLUSIONS: Safety, long storage life, light unit weight, and tolerance to environmental extremes are all characteristics that are necessary for erythrocyte substitutes to extend or replace the use of stored blood in treating battlefield casualties. |
| | |
Authors:
|
J C Bowersox; J R Hess |
Related Documents
:
|
2931578 - Microvascular adjustments during irreversible hemorrhagic shock in rat skeletal muscle. 11149578 - Persantine attenuates hemorrhagic shock-induced p-selectin expression. 8944988 - An improved blood substitute. in vivo evaluation of its hemodynamic effects. 9024828 - Heparan preserves intestinal perfusion after hemorrhage and resuscitation. 22453448 - High-resolution imaging of microvasculature in human skin in-vivo with optical coherenc... 8567508 - Beat-by-beat forearm blood flow with doppler ultrasound and strain-gauge plethysmography. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Artificial cells, blood substitutes, and immobilization biotechnology Volume: 22 ISSN: 1073-1199 ISO Abbreviation: Artif Cells Blood Substit Immobil Biotechnol Publication Date: 1994 |
Date Detail:
|
Created Date: 1994-10-20 Completed Date: 1994-10-20 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9431307 Medline TA: Artif Cells Blood Substit Immobil Biotechnol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 145-57 Citation Subset: IM |
Affiliation:
|
Letterman Army Institute of Research, Presidio of San Francisco, California 94129-6800. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Substitutes
/
therapeutic use* Disaster Planning Erythrocyte Transfusion* Hemorrhage / prevention & control Humans War* Wounds and Injuries / complications, epidemiology, etiology, therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Substitutes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hemodilution and blood substitutes.
Next Document: Assessment of blood substitutes: I. Efficacy studies in anesthetized and conscious rats with loss of...