| Trauma induced by nontraumatic coronary devices and its impact on vascular reactivity and morphology. | |
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MedLine Citation:
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PMID: 12388310 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluated the impact of low-pressure balloon devices on coronary morphology and function. An active coronary perfusion catheter (2.5-mm balloon diameter, inflation with 1 bar for 30 min) was placed in the left anterior descending coronary artery of 12 German landrace pigs under general anesthesia. After 3 mo, coronary segments with balloon contact were compared with control segments taken from the right coronary artery as to histology, vascular reactivity, and expression of endothelial nitric oxide synthase. Thirty-three balloon treated segments were analyzed. Twenty of these segments (61%) showed neointima formation. In these segments endothelium-independent relaxation induced by sodium nitroprusside was preserved. However, endothelium-dependent bradykinin-induced relaxation was significantly attenuated compared with both the control segments and the balloon-treated segments without neointima formation. In >60% of the ballooned arterial segments examined, low-pressure balloon devices induced neointima formation accompanied by reduced endothelium-dependent relaxation. Thus interventions with so-called nontraumatic coronary devices can induce relevant vascular injury, with potential adverse clinical consequences. |
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Authors:
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Jörg M Strotmann; Johann Bauersachs; Daniela Fraccarollo; Michael Kirchengast; Philipp A Schnabel; Jaromir Sykora; Georg Ertl; Wolfram Voelker |
Publication Detail:
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Type: Evaluation Studies; In Vitro; Journal Article Date: 2002-08-08 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 283 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-12 Completed Date: 2002-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H2356-62 Citation Subset: IM |
Affiliation:
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Medical University Clinic Würzburg, Germany. J.Strotmann@medizin.uni-wuerzburg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary
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adverse effects*,
instrumentation* Animals Bradykinin / pharmacology Coronary Stenosis / etiology*, pathology Coronary Vessels / pathology*, physiopathology, surgery Endothelium, Vascular / drug effects, enzymology, pathology Nitric Oxide Synthase / biosynthesis Nitric Oxide Synthase Type III Nitroprusside / pharmacology Pressure / adverse effects Swine Tunica Intima / injuries*, pathology Vasodilation* / drug effects Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 15078-28-1/Nitroprusside; 58-82-2/Bradykinin; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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