Document Detail

Trastuzumab treatment for breast cancer during pregnancy.
MedLine Citation:
PMID:  18208949     Owner:  NLM     Status:  MEDLINE    
QUESTION: One of my patients has been diagnosed with breast cancer and started treatment with trastuzumab. She has recently discovered that she is pregnant and wishes to continue the pregnancy. What are the consequences of trastuzumab treatment during pregnancy and can she continue her pregnancy?
ANSWER: Human data regarding the safety of trastuzumab during pregnancy are scarce. Only 3 case reports could be located in the published literature. Anhydramnios was observed in a case where the exposure to trastuzumab occurred during the second trimester, which reversed after discontinuation of the drug without any apparent consequences to the baby. Evidence is insufficient to provide any recommendations, but in light of the case reports, pregnancies exposed to trastuzumab during the second trimester should be closely followed with particular attention to amniotic fluid volume.
Alon Shrim; Facundo Garcia-Bournissen; Cynthia Maxwell; Dan Farine; Gideon Koren
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  54     ISSN:  1715-5258     ISO Abbreviation:  Can Fam Physician     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-22     Completed Date:  2008-02-07     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  31-2     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal / administration & dosage,  therapeutic use*
Antibodies, Monoclonal, Humanized
Antineoplastic Agents / administration & dosage,  therapeutic use*
Breast Neoplasms / drug therapy*
Drug Administration Schedule
Gestational Age
Infant, Newborn
Pregnancy Complications, Neoplastic / drug therapy*
Pregnancy Outcome
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antineoplastic Agents; P188ANX8CK/trastuzumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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