| Trastuzumab cardio-oncology: lessons learned. | |
| | |
MedLine Citation:
|
PMID: 20880820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Treatment with the humanized monoclonal antibody trastuzumab can significantly improve outcomes for patients with early or metastatic HER2-positive breast cancer. In a small proportion of patients, trastuzumab is associated with an increased risk of cardiac dysfunction. Although the mechanisms have yet to be fully established, trastuzumab may block HER2 signaling in cardiomyocytes, which is believed to be important for protecting the cardiomyocytes from stress such as that induced by treatment with anthracyclines. The risk of trastuzumab-associated cardiac dysfunction can be reduced if patients are evaluated thoroughly for risk factors before treatment (e.g., hypertension, low ejection fraction at onset, hyperglycemia, prior congestive heart failure). In addition, cardiac function must be assessed before and during the treatment period. If cardiac dysfunction occurs during treatment, early intervention can expand the possibilities of reinstitution of trastuzumab treatment. The integration of nonanthracycline adjuvant regimens offers opportunities for cardiac-compromised patients. |
| | |
Authors:
|
Cynthia Frankel |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical journal of oncology nursing Volume: 14 ISSN: 1538-067X ISO Abbreviation: Clin J Oncol Nurs Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-30 Completed Date: 2011-02-04 Revised Date: 2013-05-08 |
Medline Journal Info:
|
Nlm Unique ID: 9705336 Medline TA: Clin J Oncol Nurs Country: United States |
Other Details:
|
Languages: eng Pagination: 630-40 Citation Subset: N |
Affiliation:
|
Memorial Cancer Institute, Hollywood, FL, USA. cfrankel@mhs.net |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibodies, Monoclonal
/
administration & dosage,
adverse effects* Antibodies, Monoclonal, Humanized Antineoplastic Agents / administration & dosage, adverse effects* Breast Neoplasms / drug therapy* Clinical Trials as Topic Female Heart Diseases / chemically induced* Humans Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antineoplastic Agents; P188ANX8CK/trastuzumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chemotherapy follow-up in older adults: results of a quality-improvement project.
Next Document: The Breast Surgery Gallery: an educational and counseling tool for people with breast cancer or havi...