Document Detail

Trapping of growth factors by catechins: a possible therapeutical target for prevention of proliferative diseases.
MedLine Citation:
PMID:  15866224     Owner:  NLM     Status:  MEDLINE    
The prevention of cancer through dietary intervention is currently receiving considerable attention. Several epidemiological studies substantiate that green tea has a protective effect against a variety of malignant proliferative disorders such as lung cancer, breast cancer and prostate cancer. This preventive potential of green tea against cancer is attributed to the biologically active flavonoids called catechins. Epigallocatechin 3-o-gallate, the major catechin found in green tea, mediates diverse physiological and pharmacological actions in bringing about the regression of the tumors and also lowers the risk of nonmalignant cardiovascular proliferative diseases. Much of the current research is being focused on how these catechins specifically bring about the regression of the experimentally induced tumors both in vitro and in vivo. These catechins exert diverse physiological effects against proliferative diseases by several mechanisms, most of which are not completely characterized. This review summarizes the mechanisms by which these catechins play an essential role in regulating the process of carcinogenesis, with a special emphasis on how these catechins antagonize the growth factor-induced proliferative disorders.
Michael Xavier Doss; Shiva Prasad Potta; Jürgen Hescheler; Agapios Sachinidis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of nutritional biochemistry     Volume:  16     ISSN:  0955-2863     ISO Abbreviation:  J. Nutr. Biochem.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-03     Completed Date:  2005-07-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9010081     Medline TA:  J Nutr Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 50931 Cologne, Germany.
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MeSH Terms
Catechin / analogs & derivatives*,  metabolism,  therapeutic use*
Cell Proliferation / drug effects
Growth Substances / metabolism*
Neoplasms / prevention & control*
Platelet-Derived Growth Factor / drug effects,  metabolism
Receptor, Epidermal Growth Factor / drug effects,  physiology
Signal Transduction / drug effects
Vascular Endothelial Growth Factor A / drug effects,  physiology
Reg. No./Substance:
0/Growth Substances; 0/Platelet-Derived Growth Factor; 0/Vascular Endothelial Growth Factor A; 154-23-4/Catechin; 989-51-5/epigallocatechin gallate; EC, Epidermal Growth Factor

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