| Trapping of growth factors by catechins: a possible therapeutical target for prevention of proliferative diseases. | |
| | |
MedLine Citation:
|
PMID: 15866224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The prevention of cancer through dietary intervention is currently receiving considerable attention. Several epidemiological studies substantiate that green tea has a protective effect against a variety of malignant proliferative disorders such as lung cancer, breast cancer and prostate cancer. This preventive potential of green tea against cancer is attributed to the biologically active flavonoids called catechins. Epigallocatechin 3-o-gallate, the major catechin found in green tea, mediates diverse physiological and pharmacological actions in bringing about the regression of the tumors and also lowers the risk of nonmalignant cardiovascular proliferative diseases. Much of the current research is being focused on how these catechins specifically bring about the regression of the experimentally induced tumors both in vitro and in vivo. These catechins exert diverse physiological effects against proliferative diseases by several mechanisms, most of which are not completely characterized. This review summarizes the mechanisms by which these catechins play an essential role in regulating the process of carcinogenesis, with a special emphasis on how these catechins antagonize the growth factor-induced proliferative disorders. |
| | |
Authors:
|
Michael Xavier Doss; Shiva Prasad Potta; Jürgen Hescheler; Agapios Sachinidis |
Related Documents
:
|
21880184 - Overexpression of centromere protein h is significantly associated with breast cancer p... 21947594 - Accuracy of clinical examination, digital mammogram, ultrasound, and mri in determining... 23432624 - Immunohistochemical analysis of the monoclonal antibody 4b5 in breast tissue expressing... 22234114 - Anaplastic transformation of metastatic papillary thyroid carcinoma at shoulder mimicki... 17187484 - Her2 testing: a review of detection methodologies and their clinical performance. 6714034 - Pneumatosis coli complicating carcinoma of the colon. report of a case. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: The Journal of nutritional biochemistry Volume: 16 ISSN: 0955-2863 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2005 May |
Date Detail:
|
Created Date: 2005-05-03 Completed Date: 2005-07-22 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
|
Languages: eng Pagination: 259-66 Citation Subset: IM |
Affiliation:
|
Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 50931 Cologne, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Catechin / analogs & derivatives*, metabolism, therapeutic use* Cell Proliferation / drug effects Growth Substances / metabolism* Neoplasms / prevention & control* Platelet-Derived Growth Factor / drug effects, metabolism Receptor, Epidermal Growth Factor / drug effects, physiology Signal Transduction / drug effects Vascular Endothelial Growth Factor A / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Growth Substances; 0/Platelet-Derived Growth Factor; 0/Vascular Endothelial Growth Factor A; 154-23-4/Catechin; 989-51-5/epigallocatechin gallate; EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A genetic locus of Helicobacter pylori inversely associated with gastric intestinal metaplasia.
Next Document: Effect of postexercise carbohydrate supplementation on glucose uptake-associated gene expression in ...