| Transverse shape characteristics of cardiac myocytes from rats and humans. | |
| | |
MedLine Citation:
|
PMID: 8204795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The shape of the cardiac myocyte is complex; but, in general, it resembles that of an elliptical cylinder. Quantitative data, however, are lacking and adaptive changes in cross-sectional shape are unknown. The major and minor transverse diameters of myocytes from adult rats were measured using three independent methods: profile tracings of intact isolated myocytes, sectioned isolated myocytes, and whole-sectioned tissue. Values for major and minor diameters were virtually identical with all three methods. Using profile tracings of intact isolated myocytes, major and minor diameters were examined in isolated myocytes from freshly explanted human hearts. Five were non-failing donor hearts regarded as unsuitable for transplantation, of which 2 were normal hearts and 3 had concentric hypertrophy. Six were dilated, failing human hearts with ischemic cardiomyopathy. Major and minor diameters from the normal hearts were similar to those from normal rats. Although the number of patients was limited, the minor diameter was largest in myocytes from patients with concentric hypertrophy while the major diameter was greatest in cells from patients with ischemic cardiomyopathy. We conclude that the cross-sectional shape of structurally-intact myocytes is not altered by cell isolation. The data suggest that the transverse shape of normal human cardiac myocytes is similar to that found in rats, and that it may be altered in hypertrophy and failure. |
| | |
Authors:
|
A M Gerdes; S E Kellerman; K B Malec; D D Schocken |
Related Documents
:
|
9846935 - Noninvasive measurement of the human brachial artery pressure-area relation in collapse... 3349575 - Reactivity of isolated porcine coronary resistance arteries to cholinergic and adrenerg... 7864175 - Interaction between cgmp-dependent dilators and autoregulation in rat preglomerular vas... 16415495 - Abnormalities of the resistance vasculature in hypertension: correction by vasodilator ... 22445865 - Potential negative effects of epinephrine on carotid blood flow and etc0(2) during acti... 18957815 - Fruit and vegetable consumption and the risk of hypertension determined by self measure... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Cardioscience Volume: 5 ISSN: 1015-5007 ISO Abbreviation: Cardioscience Publication Date: 1994 Mar |
Date Detail:
|
Created Date: 1994-07-13 Completed Date: 1994-07-13 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9014943 Medline TA: Cardioscience Country: ITALY |
Other Details:
|
Languages: eng Pagination: 31-6 Citation Subset: IM |
Affiliation:
|
Department of Anatomy and Structural Biology, University of South Dakota, School of Medicine, Vermillion. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiomegaly / pathology Cardiomyopathy, Dilated / pathology Cell Separation Cytological Techniques Female Humans Hypertension / pathology Microscopy, Electron Myocardium / cytology*, pathology Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL30696/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Erratum In:
|
Cardioscience 1994 Jun;5(2):preceding 63 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of the heart and peripheral resistance in the reflex effect of group I afferent fibers on blood...
Next Document: The carotid bodies enlarge in some cases of cirrhosis of the liver.