Document Detail


Transverse myelitis in systemic lupus erythematosus--the effect of IV pulse methylprednisolone and cyclophosphamide.
MedLine Citation:
PMID:  1578449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transverse myelitis is a rare but serious complication of systemic lupus erythematosus (SLE). Standard treatment with medium to high doses of oral prednisone has been inadequate to control neurologic sequelae, and patients remain confined to a wheel chair or even die. We employed aggressive treatment in 7 patients with transverse myelitis complicating SLE with pulse methylprednisolone for acute episodes followed by pulse cyclophosphamide for a mean of 6 months; most of our patients are currently able to walk and have partial or total sphincter control.
Authors:
L Barile; C Lavalle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  19     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-10     Completed Date:  1992-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  370-2     Citation Subset:  IM    
Affiliation:
Rheumatic Diseases Unit, Hospital de Especialidades, Centro Medico La Raza, IMSS. Mexico City, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cyclophosphamide / therapeutic use*
Female
Humans
Injections, Intravenous
Lupus Erythematosus, Systemic / complications*,  drug therapy
Male
Methylprednisolone / therapeutic use*
Middle Aged
Myelitis, Transverse / drug therapy,  etiology*
Prednisolone / therapeutic use
Pulsatile Flow
Chemical
Reg. No./Substance:
50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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