Document Detail

Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?
MedLine Citation:
PMID:  8574428     Owner:  NLM     Status:  MEDLINE    
Transverse limb defects are reported in a fetus and an infant born to mothers on treatment for hypertension. One pregnancy resulted in an intrauterine death at 20 weeks, and in addition to the limb defects, there was bilateral cleft lip and palate and renal hypoxic damage. It is proposed that the drugs caused maternal hypotension which led to reduced uteroplacental blood flow, fetal hypotension and hypoxia and that the anomalies seen in the two babies are a consequence of these events.
J A Hurst; R S Houlston; A Roberts; S J Gould; W G Tingey
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical dysmorphology     Volume:  4     ISSN:  0962-8827     ISO Abbreviation:  Clin. Dysmorphol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-12     Completed Date:  1996-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9207893     Medline TA:  Clin Dysmorphol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  359-63     Citation Subset:  IM    
Oxford Regional Genetics Service, Oxford Radcliffe Trust, UK.
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MeSH Terms
Abnormalities, Drug-Induced*
Anoxia / chemically induced,  physiopathology*
Child, Preschool
Facial Bones / abnormalities*
Fetal Death / etiology
Fetus / abnormalities
Hypertension / drug therapy*
Kidney / blood supply,  pathology*
Labetalol / adverse effects
Limb Deformities, Congenital*
Middle Aged
Prazosin / adverse effects
Reg. No./Substance:
19216-56-9/Prazosin; 36894-69-6/Labetalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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