| Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension? | |
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MedLine Citation:
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PMID: 8574428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transverse limb defects are reported in a fetus and an infant born to mothers on treatment for hypertension. One pregnancy resulted in an intrauterine death at 20 weeks, and in addition to the limb defects, there was bilateral cleft lip and palate and renal hypoxic damage. It is proposed that the drugs caused maternal hypotension which led to reduced uteroplacental blood flow, fetal hypotension and hypoxia and that the anomalies seen in the two babies are a consequence of these events. |
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Authors:
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J A Hurst; R S Houlston; A Roberts; S J Gould; W G Tingey |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical dysmorphology Volume: 4 ISSN: 0962-8827 ISO Abbreviation: Clin. Dysmorphol. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-03-12 Completed Date: 1996-03-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9207893 Medline TA: Clin Dysmorphol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 359-63 Citation Subset: IM |
Affiliation:
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Oxford Regional Genetics Service, Oxford Radcliffe Trust, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced* Adult Anoxia / chemically induced, physiopathology* Child, Preschool Facial Bones / abnormalities* Female Fetal Death / etiology Fetus / abnormalities Humans Hypertension / drug therapy* Kidney / blood supply, pathology* Labetalol / adverse effects Limb Deformities, Congenital* Male Middle Aged Prazosin / adverse effects Pregnancy |
| Chemical | |
Reg. No./Substance:
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19216-56-9/Prazosin; 36894-69-6/Labetalol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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