| A Transverse and Longitudinal MR Imaging Voxel-Based Morphometry Study in Patients with Primary Cervical Dystonia. | |
| | |
MedLine Citation:
|
PMID: 20947646 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Findings of standard MR imaging examinations are usually normal in primary CD. These findings are now increasingly challenged by studies using advanced neuroimaging techniques detecting abnormalities in brain areas that may be functionally involved in the pathophysiology of CD. Our purpose was to evaluate GM volumes in patients with CD at baseline and 5 years later. MATERIALS AND METHODS: We enrolled 19 patients (F/M = 15:4, mean age = 53.2 + 11.2 years), 12 of whom were studied at baseline and again approximately 5 years later. Twenty-eight healthy volunteers acted as controls (F/M = 17:11, mean age = 47.5 + 15.6 years). The subjects were imaged with a 1.5T scanner by using a 3D T1-weighted sequence on 150 contiguous axial 1-mm-thick sections to apply VBM. RESULTS: At entry, VBM analysis disclosed significantly lower GM volumes in the left caudate head and putamen and in the premotor and primary sensorimotor cortices bilaterally in patients than in controls. No correlation was found between decreased GM volumes and patient age, severity of dystonia, or disease duration. At the 5-year follow-up, GM volumes in the left primary sensorimotor cortex in patients had decreased significantly from baseline. CONCLUSIONS: The findings obtained at entry and after a 5-year follow-up consistently showed decreased caudate, putamen, and sensorimotor cortex GM volumes in patients with CD, and they probably play a pathophysiologic role in CD. |
| | |
Authors:
|
P Pantano; P Totaro; G Fabbrini; E Raz; G M Contessa; F Tona; C Colosimo; A Berardelli |
Related Documents
:
|
2356976 - Assessment of mitral regurgitation using gated radionuclide ventriculography: analysis ... 2317906 - Noninvasive quantification of left ventricular rotational deformation in normal humans ... 11381916 - Use of image analysis and rheological studies for the control of settleability of filam... 19963816 - Thermoresponsive hydrogel with embedded magnetic nanoparticles for the implementation o... 12660106 - Parametric and non-parametric statistical analysis of dt-mri data. 18195836 - Distortion in a 2-d scan pattern generated by combining a plane mirror and a regular po... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-14 |
Journal Detail:
|
Title: AJNR. American journal of neuroradiology Volume: 32 ISSN: 1936-959X ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
|
Languages: eng Pagination: 81-4 Citation Subset: IM |
Affiliation:
|
Department of Neurological Sciences. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diffusion Tensor MR Imaging of Cerebral Gliomas: Evaluating Fractional Anisotropy Characteristics.
Next Document: Prenatal MR Imaging Detection of Deep Medullary Vein Involvement in Fetal Brain Damage.