| Transvascular fluid shift and thoracic duct lymph: analysis of lymph formation in the rat. | |
| | |
MedLine Citation:
|
PMID: 6503032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To analyze the effect of changes in interstitial fluid on lymph production, intravascular infusions of saline were given to splenectomized rats under pentobarbital anesthesia at 3 different rates (2, 3, and 4 ml/100 g of body weight) over 10 min. Change of blood volume was continuously monitored and, simultaneously, thoracic duct lymph was collected during and after the infusion. Equilibrium was attained approximately 40 min after the infusion; regardless of the infusion rate, 10% of the infused volume was incorporated into the vascular space and 90% was filtered into the extravascular space. Thus, the amount of transvascular fluid shift showed a linear relationship with the infused volume. However, the drainage from thoracic duct lymph amounted to 5.9%, 11.4%, and 17.8% of the infused saline volume when given at the rate of 2, 3, and 4 ml/100 g, respectively. The relation of lymph flow and infused volume could be regarded as a nonlinear system. By means of a simulation study, this relation was found to be attributed to the nonlinearity of conductance for fluid movement from tissue to lymph duct, which was only one sixth of that determined for the capillary membrane. The drainage of lymph protein following the infusion was only about 50% of that expected from the interstitial protein concentration in even distribution of the infused saline. These characteristics of interstitial fluid space play an important role in absorbing water and, hence, buffering changes in circulating blood volume after volume loading. |
| | |
Authors:
|
H Nose; S Yamada; T Morimoto |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Japanese journal of physiology Volume: 34 ISSN: 0021-521X ISO Abbreviation: Jpn. J. Physiol. Publication Date: 1984 |
Date Detail:
|
Created Date: 1985-01-16 Completed Date: 1985-01-16 Revised Date: 2007-03-21 |
Medline Journal Info:
|
Nlm Unique ID: 2985184R Medline TA: Jpn J Physiol Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 713-29 Citation Subset: IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure Blood Vessels / metabolism* Blood Volume / drug effects Body Fluids / metabolism* Body Water / metabolism Lymph / metabolism* Male Models, Biological Proteins / metabolism Rats Sodium Chloride / pharmacology Thoracic Duct / metabolism* Venous Pressure |
| Chemical | |
Reg. No./Substance:
|
0/Proteins; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of a brief treatment with saponin on the contractile and electrical activities of isolated u...
Next Document: Mechanism of calcium efflux from isolated bovine adrenal chromaffin cells.