Document Detail


Transvascular fluid flux from the pulmonary vasculature at rest and during exercise in horses.
MedLine Citation:
PMID:  16269434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise causes changes in pulmonary haemodynamics through redistribution of blood flow, increase in the pulmonary surface area, and increase in pulmonary vascular pressures. These changes contribute to the increase in fluid exchange across the alveolar-capillary barrier. To determine the extent of the fluid exchange across the alveolar-capillary barrier at rest and during exercise, six horses were exercised on a high-speed treadmill until fatigue. Arterial and mixed venous blood were sampled at rest and during exercise and recovery. Blood volume changes across the lung (DeltaBV; measured in percentage) were calculated from changes in plasma protein and haemoglobin concentration, and haematocrit. Cardiac output (Q) was calculated using the Fick equation. Fluid flux (J(V-A); measured in l min(-1)) across the alveolar-capillary barrier was then quantified based on Q and DeltaBV. At rest, no fluid movement occurred across the pulmonary vasculature (0.6 +/- 0.6 l min(-1)). During exercise, the amount of fluid moved from the pulmonary circulation was 8.3 +/- 1.3 l min(-1) at 1 min, 6.4 +/- 2.9 l min(-)(1) at 2 min, 10.1 +/- 1.0 l min(-1) at 3 min, 12.9 +/- 2.5 l min(-1) at 4 and 9.6 +/- 1.5 l min(-1) at fatigue (all P < 0.0001). Erythrocyte volume decreased by 6% (P < 0.01) across the lungs, which decreased the colloid osmotic gradient in the pulmonary vasculature. Decrease colloid osmotic gradient along with increased hydrostatic forces in the pulmonary vasculature would enhance displacement of fluid into the pulmonary interstitium. In conclusion, exercise caused large increases in transpulmonary fluid fluxes in horses. Here, we present a simple method to calculate transpulmonary fluid fluxes in different species, which can be used to elucidate mechanisms of lung fluid balance in vivo.
Authors:
Modest Vengust; Henry Staempfli; Laurent Viel; George Heigenhauser
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-03
Journal Detail:
Title:  The Journal of physiology     Volume:  570     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-02-23     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  397-405     Citation Subset:  IM    
Affiliation:
Veterinary Faculty, University of Ljubljana, Slovenia. modest.vengust@vf.uni-lj.si
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Proteins / analysis
Blood Volume / physiology
Blood-Air Barrier / physiology*
Cardiac Output / physiology
Erythrocytes
Extravascular Lung Water / physiology*
Female
Fluid Shifts
Hemoglobins / analysis
Horses / physiology*
Lung / blood supply,  physiology*
Male
Physical Conditioning, Animal
Physical Exertion / physiology*
Pulmonary Artery / physiology*
Pulmonary Gas Exchange / physiology
Pulmonary Veins / physiology*
Pulmonary Ventilation / physiology
Pulmonary Wedge Pressure / physiology
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Hemoglobins
Comments/Corrections

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