Document Detail

Transvaginal amniotic puncture for cytogenetic evaluation of missed abortions.
MedLine Citation:
PMID:  9415516     Owner:  NLM     Status:  MEDLINE    
Transvaginal amniotic puncture (TAP) was performed on 20 consecutive missed abortions immediately prior to dilatation and evacuation and the cytogenetic results compared. The information received from products of conception (POC) and TAP was in concordance in only 5 of 20 (25%) cases. Tissue obtained from POC yielded cells in all instances. However, only 3 of 20 POC samples yielded findings other than normal female. In contrast, 92.8% of the conclusive diagnoses would have been achieved by TAP alone. These data strongly suggest that TAP is superior to POC for accurate cytogenetic assessment of missed abortion and should lead to a reevaluation of our current understanding and management of pregnancy loss.
M Zilberstein; M M Seibel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  44     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1997  
Date Detail:
Created Date:  1998-01-27     Completed Date:  1998-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  IM    
Faulkner Center for Reproductive Medicine, Boston, Mass. 02130, USA.
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MeSH Terms
Abortion, Missed / diagnosis,  genetics*
Amniocentesis / methods*
Amnion / ultrasonography
Chromosome Aberrations / diagnosis,  genetics*
Chromosome Disorders
Gestational Age
Pregnancy Trimester, First
Punctures / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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