Document Detail


Transurethral resection of the prostate immediately after high-intensity focused ultrasound treatment for prostate cancer.
MedLine Citation:
PMID:  20969640     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate the long-term outcomes of transurethral resection of the prostate (TURP) immediately after high-intensity focused ultrasound (HIFU) treatment for prostate cancer (CaP).
METHODS: The present retrospective study included 65 CaP patients who underwent HIFU alone and 64 patients who underwent TURP immediately after HIFU. HIFU treatment was carried out using a Sonablate-500 HIFU device (Focus Surgery, Indianapolis, IN, USA). International Prostate Symptom Score (IPSS) and the occurrence of urinary complications, such as urethral stricture during follow-up, were statistically compared between groups.
RESULTS: Clinical stage tended to be lower for the HIFU+TURP group (P=0.0311), but none of the preoperative parameters differed significantly between groups. Both catheterization time (P<0.0001) and post-treatment IPSS (P<0.0001) at 6, 12, and 24months after treatment differed significantly between groups. Urethral strictures were noted in 16 (24.6%) of the HIFU-only patients and seven (10.9%) of the HIFU+TURP patients. Bladder neck contracture was noted in 11 (68.8%) of the patients with urethral stricture in the HIFU-only group, but in just two (28.6%) of the patients with urethral stricture in the HIFU+TURP group. Multiple logistic regression analyses showed that TURP resection volume (P=0.0118) was a strong factor for the prevention of urethral stricture.
CONCLUSIONS: Our results suggest that combining HIFU with an immediately following TURP improves post-treatment urinary status without causing additional morbidity.
Authors:
Makoto Sumitomo; Junichi Asakuma; Akinori Sato; Keiichi Ito; Kazuhiko Nagakura; Tomohiko Asano
Publication Detail:
Type:  Journal Article     Date:  2010-10-04
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  17     ISSN:  1442-2042     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  924-30     Citation Subset:  IM    
Copyright Information:
© 2010 The Japanese Urological Association.
Affiliation:
Department of Urology, National Defense Medical College, Tokorozawa, Saitama Department of Urology, Musashino Yohwakai Hospital, Musashino, Tokyo, Japan. mh712sumitomo@ybb.ne.jp
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Comment In:
Int J Urol. 2010 Nov;17(11):930   [PMID:  20969641 ]

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