Document Detail


Transtympanic pilocarpine in tinnitus.
MedLine Citation:
PMID:  14689616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 48 patients who had neurosensory hypoacusia and whose main complaint was tinnitus, a 1% pilocarpine solution or a 2% carbachol Isopto solution was placed in the tympanic cavity by means of a No. 26 pencil-tipped lumbar puncture needle through the front quadrant of the eardrum. Patients were chosen without regard for age, gender, or topographical damage of the acoustic pathway. Evaluation of the drug's effect was performed audiometrically by masking with the minimum intensity of the pure sound or narrow band that most closely resembled the patients' own noises. The results of this medical therapy were positive and ranged from complete annulment to attenuation of the tinnitus, which was confirmed by audiometric masking 30 minutes after the intratympanic injection. These positive results reached 50% and would have been higher if the several cases submitted by accident insurance companies and cases of presbyacusia were discarded. The unsatisfactory element of the study was the short-term effect of the therapy, which usually lasted no more than 12-72 hours. Tinnitus reappeared in all patients at its original intensity. The best results involved the use of carbachol as compared with pilocarpine. The decision to replace pilocarpine with carbachol was based on the idea that the inhibitory cholinergic efferent pathways are damaged before the afferent pathways. The use of pilocarpine depends on efficient cholinergic functioning, as its activity is as an indirect agonist (i.e., to annul the cholinesterase enzyme).
Authors:
E DeLucchi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The international tinnitus journal     Volume:  6     ISSN:  0946-5448     ISO Abbreviation:  Int Tinnitus J     Publication Date:  2000  
Date Detail:
Created Date:  2003-12-23     Completed Date:  2004-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9612993     Medline TA:  Int Tinnitus J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-40     Citation Subset:  IM    
Affiliation:
Sociedad Otorrinolaringologica de Chile, Concepción, Chile.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Audiometry, Pure-Tone
Auditory Threshold / drug effects*
Carbachol / therapeutic use*
Cholinergic Agonists / therapeutic use*
Ear, Middle
Female
Humans
Injections
Male
Middle Aged
Muscarinic Agonists / therapeutic use*
Pilocarpine / therapeutic use*
Tinnitus / drug therapy*
Treatment Outcome
Tympanic Membrane
Chemical
Reg. No./Substance:
0/Cholinergic Agonists; 0/Muscarinic Agonists; 51-83-2/Carbachol; 92-13-7/Pilocarpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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