Document Detail

Transtubular leakage of glomerular filtrate in human acute renal failure.
MedLine Citation:
PMID:  495725     Owner:  NLM     Status:  MEDLINE    
Ten postcardiac surgical patients with acute renal failure (ARF) were infused with inulin and dextran 40. Plasma and urine were then submitted to gel-permeation chromatography to ascertain the apparent fractional clearance profile for the dextrans. Compared to normal volunteer controls, the fractional clearance profile was substantially elevated for dextran molecules in the Einstein-Stokes radius (r) range 20-40 A. For the smaller molecules (r = 20-28 A), fractional dextran clearance in ARF was frequently in excess of unity. A simple mass conservation model which assumes that the "true" fractional dextran clearance profile for the glomerulus (in Bowman's space) in ARF is the same as that for normal controls, when applied to the experimental observations, revealed that in ARF, on the average, 50% of filtered inulin is lost by tubular backleakage. Furthermore, the model permitted an estimate of the permeability properties of the damaged tubular wall. This indicated tubular permeability not unlike that of the normal glomerulus to dextran molecules with r less than 30 A, but relative impermeability to larger dextran molecules.
B D Myers; F Chui; M Hilberman; A S Michaels
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  237     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1979-12-27     Completed Date:  1979-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F319-25     Citation Subset:  IM    
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MeSH Terms
Cardiac Surgical Procedures
Dextrans / diagnostic use
Glomerular Filtration Rate
Inulin / diagnostic use
Kidney / physiopathology*
Kidney Failure, Acute / etiology,  physiopathology*
Kidney Function Tests
Middle Aged
Postoperative Complications
Reg. No./Substance:
9004-54-0/Dextrans; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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