| Transthoracic bioimpedance can measure extravascular lung water in acute lung injury. | |
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MedLine Citation:
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PMID: 8903454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We used a porcine endotoxemic model of acute lung injury to compare extravascular lung water (EVLW) measured by right transthoracic bioimpedance to postmortem gravimetric EVLW measurements. Adult pigs were randomized into control (N = 5) or endotoxin groups [150 microgram/kg Escherichia coli lipopolysaccharide B for 1 hr followed by 3 hr of resuscitation for a thermodilution cardiac output less than 90% of baseline using either isotonic saline (N = 5) or isooncotic albumin (N = 5)]. Right lung resistance was measured using a novel electrode array and a highly sensitive analyzer and was used to calculate right lung resistivity. At the end of the experiment, animals in the endotoxin-albumin group had higher gravimetric EVLWs than those in the endotoxin-saline or control groups (P < 0.05). Right lung resistivity corrected for body weight significantly correlated with gravimetric EVLW (r2 = 0.49; SEE = 0.96; P = 0.0038). Using multiple regression analysis, a predictive equation for EVLW based on right lung resistivity, body weight, and mean pulmonary artery pressure was generated (r2 = 0.81; SEE = 0.60; P < 0.0001). These results demonstrate that right lung resistivity measurements can provide a noninvasive estimate of EVLW. In addition, crystalloid may be preferable to colloid for fluid resuscitation in noncardiogenic pulmonary edema. |
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Authors:
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D M Nierman; D I Eisen; E D Fein; E Hannon; J I Mechanick; E Benjamin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of surgical research Volume: 65 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-12-03 Completed Date: 1996-12-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 101-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, The Mount Sinai Medical Center, New York, New York 10029-6574, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Composition / physiology Electric Impedance* Electrophysiology / instrumentation Extravascular Lung Water / metabolism* Female Hematocrit Hemodynamics / physiology Lung / metabolism*, pathology Lung Diseases / metabolism* Organ Size Oxygen / blood Pulmonary Circulation Pulmonary Edema / chemically induced, metabolism* Regression Analysis Resuscitation |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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