| Transstenotic pressure gradients: measurement in swine--retrospectively ECG-gated 3D phase-contrast MR angiography versus endovascular pressure-sensing guidewires. | |
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MedLine Citation:
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PMID: 18024452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To prospectively evaluate the hypothesis that retrospectively electrocardiographically gated phase contrast with vastly undersampled isotropic projection reconstruction (VIPR) magnetic resonance (MR) angiography data sets can be used to measure transstenotic pressure gradients (TSPGs) in vivo. MATERIALS AND METHODS: TSPGs were calculated by using phase-contrast VIPR MR angiography data sets; measurements obtained with a pair of endovascular pressure-sensing guidewires served as a reference standard. With institutional animal care and use committee approval, 12 swine underwent surgical creation of stenoses at the left common carotid, right renal, and left external iliac arteries. The percentage stenosis and reference diameter of the lesions were calculated from conventional digital subtraction angiograms. A pair of 0.014-inch pressure-sensing guidewires was placed in tandem; sensors 1 cm distal and 1 cm proximal to the lesions measured the mean TSPG. Phase-contrast VIPR phase difference images were analyzed with an iterative technique based on the Navier-Stokes equations to determine the mean TSPG. Pearson product correlation was calculated, and Bland-Altman plots were generated to determine the degree of agreement between the two methods. RESULTS: Twenty-one lesions (12 carotid, nine iliac; mean percentage stenosis, 52.4%; range, 29.8%-64.9%; mean reference diameter, 3.4 mm; range, 2.4-5.6 mm) were analyzed. For carotid and iliac lesions, phase-contrast VIPR and guidewire TSPG measurements were highly correlated (r = 0.952, P < .001). Bland-Altman plots (bias, 0.86 mm Hg; limits of agreement: -6.17 to 7.88 mm Hg) showed good agreement. Measurements in renal lesions (n = 9) were poorly correlated (r = -0.081, P = .835) and were excluded because of image degradation secondary to respiratory motion. CONCLUSION: Phase-contrast MR angiography with VIPR enables reliable measurements of TSPG in carotid and iliac lesions that are comparable to those obtained with endovascular pressure-sensing guidewires. However, further work to compensate for respiratory motion is required to extend this technique to the renal arteries. |
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Authors:
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Darren P Lum; Kevin M Johnson; Russell K Paul; Aquilla S Turk; Daniel W Consigny; Julie R Grinde; Charles A Mistretta; Thomas M Grist |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiology Volume: 245 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-20 Completed Date: 2007-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 751-60 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University of Wisconsin Hospital and Clinics, 600 Highland Ave, CSC E3/311, Madison, WI 53792, USA. lum@wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / diagnosis*, physiopathology Carotid Stenosis / diagnosis, physiopathology Constriction, Pathologic Electrocardiography* Iliac Artery / pathology, physiopathology Imaging, Three-Dimensional* Magnetic Resonance Angiography / methods* Pressure Prospective Studies Swine |
| Grant Support | |
ID/Acronym/Agency:
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R01HL072260-02/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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Radiology. 2007 Dec;245(3):617-8
[PMID:
18024442
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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