| Transsplenic portal scintigraphy using 99mTc-mebrofenin in normal dogs. | |
| | |
MedLine Citation:
|
PMID: 17508519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Transsplenic portal scintigraphy using sodium pertechnetate is superior to per-rectal portal scintigraphy due to improved visualization of the portal vasculature with decreased patient and personnel exposure. The purpose of this study was to describe the use of 99mTc-mebrofenin, the radiopharmaceutical of choice for the evaluation of hepatic function, in place of pertechnetate for transsplenic portal scintigraphy in normal dogs. Sixteen juvenile dogs underwent transsplenic portal scintigraphy using 37-130 MBq 99mTc-mebrofenin in a 0.2-0.5 ml volume. After the initial dynamic acquisition obtained at 4 frames/s in right lateral recumbency, static right lateral, and ventral views were obtained at 5, 10, 15, 20, 25, 30, 40, 50, and 60 min. A nuclear angiogram of the splenic and portal veins was visible in all dogs, followed by rapid distribution of the radiopharmaceutical in the liver. Hepatic morphology was more easily defined than with pertechnetate. Transit time could not be calculated due to the high hepatic extraction of 99mTc-mebrofenin. Mean +/- SD shunt fraction was 0.8 +/- 0.8%. Time to peak liver activity was 3.1 +/- 1.1 min, and hepatic excretion T1/2 was 19.4 +/- 6.3 min. No visible blood pool and cardiac activity was seen after 5 min. The mean +/- SD time to visualization of defined biliary activity was 8.8 +/- 2.9 min. Absorption from the spleen was significantly higher than that reported for pertechnetate (87.9 +/- 8.2%, vs. 52.5 +/- 19.1%). 99mTc-mebrofenin can be used in place of pertechnetate for transsplenic portal scintigraphy, with the advantage of combining quantitative parameters of liver function with the already known advantage of transsplenic portal scintigraphy. |
| | |
Authors:
|
Federica Morandi; Robert C Cole; Rita L Echandi; Gregory B Daniel |
Related Documents
:
|
7970439 - Pharmacological cardiac stress: when and how? 6707369 - The pacing stress test: thallium-201 myocardial imaging after atrial pacing. diagnostic... 3587799 - Improvement in indices of myocardial ischaemia in a case of hypertrophic obstructive ca... 8065009 - Assessment of quantitative exercise thallium-201 emission computed tomography in patien... 20201789 - Peak treadmill exercise echocardiography. 11382729 - Alleviation of myocardial ischemia after kawasaki disease by heparin and exercise therapy. 12869359 - Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructiv... 1206469 - Enhancement of experienced sexual arousal in response to erotic stimuli through misattr... 19697999 - Effects of low-level laser irradiation on rat skeletal muscle injury after eccentric ex... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association Volume: 48 ISSN: 1058-8183 ISO Abbreviation: Vet Radiol Ultrasound Publication Date: 2007 May-Jun |
Date Detail:
|
Created Date: 2007-05-18 Completed Date: 2007-06-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9209635 Medline TA: Vet Radiol Ultrasound Country: United States |
Other Details:
|
Languages: eng Pagination: 286-91 Citation Subset: IM |
Affiliation:
|
Department of Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, USA. fmorandi@utk.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dogs* Female Liver / radionuclide imaging Portal System / radionuclide imaging* Radionuclide Imaging / methods, veterinary* Radiopharmaceuticals / diagnostic use Sodium Pertechnetate Tc 99m / diagnostic use* Spleen / radionuclide imaging |
| Chemical | |
Reg. No./Substance:
|
0/Radiopharmaceuticals; 23288-60-0/Sodium Pertechnetate Tc 99m |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Repeatability of Doppler ultrasonographic measurement of equine digital blood flow.
Next Document: Comparison of isodose distributions in canine brain in heterogeneity-corrected versus uncorrected tr...