Document Detail

Transsplenic portal scintigraphy using 99mTc-mebrofenin in normal dogs.
MedLine Citation:
PMID:  17508519     Owner:  NLM     Status:  MEDLINE    
Transsplenic portal scintigraphy using sodium pertechnetate is superior to per-rectal portal scintigraphy due to improved visualization of the portal vasculature with decreased patient and personnel exposure. The purpose of this study was to describe the use of 99mTc-mebrofenin, the radiopharmaceutical of choice for the evaluation of hepatic function, in place of pertechnetate for transsplenic portal scintigraphy in normal dogs. Sixteen juvenile dogs underwent transsplenic portal scintigraphy using 37-130 MBq 99mTc-mebrofenin in a 0.2-0.5 ml volume. After the initial dynamic acquisition obtained at 4 frames/s in right lateral recumbency, static right lateral, and ventral views were obtained at 5, 10, 15, 20, 25, 30, 40, 50, and 60 min. A nuclear angiogram of the splenic and portal veins was visible in all dogs, followed by rapid distribution of the radiopharmaceutical in the liver. Hepatic morphology was more easily defined than with pertechnetate. Transit time could not be calculated due to the high hepatic extraction of 99mTc-mebrofenin. Mean +/- SD shunt fraction was 0.8 +/- 0.8%. Time to peak liver activity was 3.1 +/- 1.1 min, and hepatic excretion T1/2 was 19.4 +/- 6.3 min. No visible blood pool and cardiac activity was seen after 5 min. The mean +/- SD time to visualization of defined biliary activity was 8.8 +/- 2.9 min. Absorption from the spleen was significantly higher than that reported for pertechnetate (87.9 +/- 8.2%, vs. 52.5 +/- 19.1%). 99mTc-mebrofenin can be used in place of pertechnetate for transsplenic portal scintigraphy, with the advantage of combining quantitative parameters of liver function with the already known advantage of transsplenic portal scintigraphy.
Federica Morandi; Robert C Cole; Rita L Echandi; Gregory B Daniel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association     Volume:  48     ISSN:  1058-8183     ISO Abbreviation:  Vet Radiol Ultrasound     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-05-18     Completed Date:  2007-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9209635     Medline TA:  Vet Radiol Ultrasound     Country:  United States    
Other Details:
Languages:  eng     Pagination:  286-91     Citation Subset:  IM    
Department of Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, USA.
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MeSH Terms
Liver / radionuclide imaging
Portal System / radionuclide imaging*
Radionuclide Imaging / methods,  veterinary*
Radiopharmaceuticals / diagnostic use
Sodium Pertechnetate Tc 99m / diagnostic use*
Spleen / radionuclide imaging
Reg. No./Substance:
0/Radiopharmaceuticals; 23288-60-0/Sodium Pertechnetate Tc 99m

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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