| Transsphenoidal adenomectomy for GH-, PRL- and ACTH-secreting pituitary tumours: outcome analysis in a series of 125 patients. | |
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MedLine Citation:
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PMID: 15624082 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transsphenoidal surgery (TSS) is a well recognised treatment for secreting pituitary adenomas, however a very wide variation of clinical outcomes and recurrence rates has been reported, depending on the different criteria used to define the cure. We reported the clinical outcome of a large series of patients operated on for a secreting pituitary adenoma according to the most recent stringent criteria of biochemical remission nowadays accepted. One hundred and twenty-five consecutive patients with a secreting pituitary adenoma (42 PRL-, 67 GH- and 16 ACTH-secreting adenomas) who were operated on by the two same neurosurgeons were considered for the study. Biochemical remission of disease was achieved in 56% of patients; 78% for patients with microadenoma and 47% for patients with macroadenomas, respectively. No cases of mortality or major immediate postoperative complications were observed. Tumour size, high hormone levels and dural invasion were significantly correlated to a poor surgical outcome. The recurrence rates ranged between 0 and 24%, being higher for PRL-secreting tumours. In conclusion, TSS is safe and effective in secreting pituitary tumours. It is still the first treatment for GH- and ACTH-secreting adenomas, whereas in patients with prolactinomas, surgery should be reserved for cases of resistance or intolerance to dopamine agonists. |
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Authors:
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V Esposito; A Santoro; G Minniti; M Salvati; G Innocenzi; G Lanzetta; G Cantore |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 25 ISSN: 1590-1874 ISO Abbreviation: Neurol. Sci. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-29 Completed Date: 2005-01-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 251-6 Citation Subset: IM |
Affiliation:
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Department of Neurological Sciences, IRCCS-NEUROMED, University of Rome La Sapienza, Parco Tecnologico, Via Atinense, I-86077 Pozzilli (IS), Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acromegaly Adenoma / metabolism*, surgery* Adrenocorticotropic Hormone / metabolism* Adult Female Follow-Up Studies Human Growth Hormone / metabolism* Humans Male Neurosurgical Procedures* Pituitary Neoplasms / metabolism*, surgery* Prolactin / metabolism* Retrospective Studies Sphenoid Bone Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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12629-01-5/Human Growth Hormone; 9002-60-2/Adrenocorticotropic Hormone; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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