| Transpososome dynamics and regulation in Tn10 transposition. | |
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MedLine Citation:
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PMID: 17092825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tn10 is a bacterial transposon that transposes through a non-replicative mechanism. This mode of DNA transposition is widely used in bacteria and is also used by "DNA-based" transposons in eukaryotes. Tn10 has served as a paradigm for this mode of transposition and continues to provide novel insights into how steps in transposition reactions occur and how these steps are regulated. A common feature of transposition reactions is that they require the formation of a higher order protein-DNA complex called a transpososome. A major objective in the last few years has been to better understand the dynamics of transpososome assembly and progression through the course of transposition reactions. This problem is particularly interesting in the Tn10 system because two important host proteins, IHF and H-NS, have been implicated in regulating transpososome assembly and/or function. Interestingly, H-NS is an integral part of stress response pathways in bacteria, and its function is known to be sensitive to changes in environmental conditions. Consequently, H-NS may provide a means of allowing Tn10 to responed to changing environmental conditions. The current review focuses on the roles of both IHF and H-NS on Tn10 transposition. |
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Authors:
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David B Haniford |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Critical reviews in biochemistry and molecular biology Volume: 41 ISSN: 1040-9238 ISO Abbreviation: Crit. Rev. Biochem. Mol. Biol. Publication Date: 2006 Nov-Dec |
Date Detail:
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Created Date: 2006-11-09 Completed Date: 2007-01-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8903774 Medline TA: Crit Rev Biochem Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 407-24 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Western Ontario, London, Ontario, Canada. haniford@uwo.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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metabolism Calcium / metabolism DNA / chemistry, genetics, metabolism DNA Transposable Elements* DNA-Binding Proteins / metabolism Heparin / metabolism Integration Host Factors / metabolism Nucleic Acid Conformation Recombination, Genetic* Transposases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/DNA Transposable Elements; 0/DNA-Binding Proteins; 0/H-NS protein, bacteria; 0/Integration Host Factors; 0/Tn10 transposase; 7440-70-2/Calcium; 9005-49-6/Heparin; 9007-49-2/DNA; EC 2.7.7.-/Transposases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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