Document Detail

Transport of uric acid and hypoxanthine across the isolated guinea pig placenta.
MedLine Citation:
PMID:  610763     Owner:  NLM     Status:  MEDLINE    
Transport of uric acid and hypoxanthine across the isolated guinea pig placenta is investigated quantitatively. The clearances measured are independent of concentration. It is shown that the uric acid transport is not greatly influenced by variations in flow, so it is concluded that the uric acid transport is membrane limited. The clearance of hypoxanthine is even less than the uric acid clearance, so hypoxanthine transport is also membrane limited. Xanthine oxidase is shown to be present in the uterine tissues, and an apparent Km and a maximum velocity have been determined.
B K van Kreel; J P van Dijk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  32     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1977  
Date Detail:
Created Date:  1978-06-28     Completed Date:  1978-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  260-5     Citation Subset:  IM    
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MeSH Terms
Guinea Pigs
Hypoxanthines / metabolism*
Maternal-Fetal Exchange
Placenta / enzymology,  metabolism*
Uric Acid / metabolism*
Uterus / enzymology
Xanthine Oxidase / metabolism
Reg. No./Substance:
0/Hypoxanthines; 69-93-2/Uric Acid; EC Oxidase

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