| Transport of quinolinic acid into rabbit and rat brain. | |
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MedLine Citation:
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PMID: 2956529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The transport metabolism of [3H]quinolinic acid in the central nervous system of rabbits and rats were studied. In vitro [3H]quinolinic acid was not readily accumulated by isolated choroid plexus. After the intraventricular injection of tracer quantities of [3H]quinolinic acid, the [3H]quinolinic acid did not enter the brain as readily as concurrently injected [14C]mannitol and was not metabolized. The permeability-surface area constant for [3H]quinolinic acid at the rat blood-brain barrier was 1.5 +/- 1.3 X 10(-5) sec-1 compared to 2.8 +/- 0.4 X 10(-5) sec-1 for [3H]mannitol. Our results suggest that: 1) [3H]quinolinic acid is transported in the CNS by passive diffusion and 2) is not metabolized. |
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Authors:
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T M Kitt; R Spector |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurochemical research Volume: 12 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1987-09-11 Completed Date: 1987-09-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 625-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / metabolism* Blood-Brain Barrier* Brain / metabolism* Choroid Plexus / metabolism Pyridines / metabolism* Quinolinic Acid Quinolinic Acids / metabolism* Rabbits Rats |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Pyridines; 0/Quinolinic Acids; 89-00-9/Quinolinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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