Document Detail


Transport of quinolinic acid into rabbit and rat brain.
MedLine Citation:
PMID:  2956529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The transport metabolism of [3H]quinolinic acid in the central nervous system of rabbits and rats were studied. In vitro [3H]quinolinic acid was not readily accumulated by isolated choroid plexus. After the intraventricular injection of tracer quantities of [3H]quinolinic acid, the [3H]quinolinic acid did not enter the brain as readily as concurrently injected [14C]mannitol and was not metabolized. The permeability-surface area constant for [3H]quinolinic acid at the rat blood-brain barrier was 1.5 +/- 1.3 X 10(-5) sec-1 compared to 2.8 +/- 0.4 X 10(-5) sec-1 for [3H]mannitol. Our results suggest that: 1) [3H]quinolinic acid is transported in the CNS by passive diffusion and 2) is not metabolized.
Authors:
T M Kitt; R Spector
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurochemical research     Volume:  12     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-09-11     Completed Date:  1987-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  625-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants / metabolism*
Blood-Brain Barrier*
Brain / metabolism*
Choroid Plexus / metabolism
Pyridines / metabolism*
Quinolinic Acid
Quinolinic Acids / metabolism*
Rabbits
Rats
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Pyridines; 0/Quinolinic Acids; 89-00-9/Quinolinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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