Document Detail

Transport of premature infants is associated with increased risk for intraventricular haemorrhage.
MedLine Citation:
PMID:  20584801     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intraventricular haemorrhages (IVH) greatly impact the outcome of very low birth weight (VLBW) infants. This study examines the correlation between inter-hospital transport and the incidence and severity of IVH in VLBW infants in a large cohort of data.
METHODS: The US National Inpatient Sample Database (NIS) and its KID subportion were analysed for the years 1997-2004. Infants <1500 g were included in the study and were classified into transport and inborn groups. Groups were further classified according to birth weight into <1000 g and 1000-1499 g. IVH and severe IVH (grades 3-4) were compared between groups and subgroups. Adjusted OR for IVH or severe IVH in correlation with inter-hospital transport were calculated using logistic regression models while controlling for clinical and demographic confounders. We examined changing trends of the incidence of IVH, incidence of neonatal transport and OR for IVH in correlation with neonatal transport in VLBW infants over the years.
RESULTS: A total of 67 596 VLBW infants were included in the study. Overall incidence of IVH in the sample was 14.7%; the transport group had more IVH compared to inborn group (27.4% vs 13.42%): adjusted OR 1.75 (95% CI 1.64 to 1.86; p<0.001). Severe IVH was higher in the transport group compared to the inborn group (44.1% vs 32.9%); adjusted OR 1.44 (95% CI 1.22 to 1.70, p=0.001). Similar results were demonstrated in weight-based subgroups. There was increasing trends for neonatal transport and for IVH over the years (p<0.001 for both) with no significant change in the OR for IVH in transported infants.
CONCLUSION: Inter-hospital transport of VLBW Infants is correlated with increased incidence and severity of IVH. This correlation has remained constant over the recent years.
Mohamed A Mohamed; Hany Aly
Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2010-06-28
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  95     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F403-7     Citation Subset:  AIM; IM    
Newborn Services Department, The George Washington University Medical Center, Washington, DC 20037, USA.
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MeSH Terms
Birth Weight
Cerebral Hemorrhage / epidemiology,  etiology*
Epidemiologic Methods
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology,  etiology*
Infant, Very Low Birth Weight
Transportation of Patients / statistics & numerical data*,  trends
United States / epidemiology

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