| Transport and metabolism of pantothenic acid by rat kidney. | |
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MedLine Citation:
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PMID: 6696896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transport of [14C]pantothenic acid was studied using brush-border membrane vesicles prepared from rat kidney. In the presence of a Na+ gradient an accumulation of pantothenic acid 3-fold above equilibrium was observed. The Km and Vmax found were 7.30 microM and 23.8 pmol/mg protein per min, respectively. Isolated perfused rat kidneys were employed to study excretion of pantothenic acid at various concentrations in the perfusate. At physiological plasma concentrations, the filtered pantothenic acid was largely reabsorbed by the active process observed in the vesicles. At higher concentrations, pantothenic acid was found to undergo tubular secretion. Penicillin inhibited this secretory process indicating that both compounds share a secretory mechanism. Live animal studies indicated that the only compound excreted after injection of [14C]pantothenic acid was free pantothenic acid. After 1 week only 38% of the administered dose was excreted in the urine, indicating that effective conservation was taking place in the whole animal. |
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Authors:
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L M Karnitz; C J Gross; L M Henderson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 769 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-04-04 Completed Date: 1984-04-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 486-92 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Kidney / metabolism*, ultrastructure Male Microvilli / metabolism Pantothenic Acid / metabolism* Penicillins / pharmacology Perfusion Rats Rats, Inbred Strains Sodium / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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5 R01-AM19012/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Penicillins; 7440-23-5/Sodium; 79-83-4/Pantothenic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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