| Transport characteristics of folates in cerebrospinal fluid; a study utilizing doubly labeled 5-methyltetrahydrofolate and 5-formyltetrahydrofolate. | |
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MedLine Citation:
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PMID: 5314166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum disappearance curves in dogs after the intravenous injection of radioactive methotrexate, 5-methyltetrahydrofolate, 5-formyltetrahydrofolate, and folic acid followed first-order kinetics with half-disappearance times ranging from 1.3 to 9 hr respectively. Equilibration of spinal fluid tritium levels with those in serum was rapid (3.0 hr) for both of the reduced folates but was not observed at any time after folic acid and methotrexate. The only radioactive folate identified in the spinal fluid after intravenous injection of either 5-formyltetrahydrofolate or folic acid, as well as 5-methyltetrahydrofolate was 5-methyltetrahydrofolate. These findings indicated that 5-methyltetrahydrofolate was taken up preferentially into the spinal fluid and that the other folate congeners were converted to this compound before uptake. Diphenylhydantoin administration did not alter the uptake of 5-methyltetrahydrofolate into the spinal fluid but was associated with reduced renal excretion of this compound. |
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Authors:
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M Levitt; P F Nixon; J H Pincus; J R Bertino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 50 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1971 Jun |
Date Detail:
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Created Date: 1971-07-15 Completed Date: 1971-07-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1301-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Macrocytic
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drug therapy Animals Biological Transport Blood-Brain Barrier Carbon Isotopes Chromatography, Gel Dogs Female Folic Acid / blood, cerebrospinal fluid*, metabolism* Kinetics Leucovorin / cerebrospinal fluid*, metabolism* Male Phenytoin / pharmacology Tritium |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 10028-17-8/Tritium; 57-41-0/Phenytoin; 58-05-9/Leucovorin; 59-30-3/Folic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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