Document Detail


Transport characteristics of folates in cerebrospinal fluid; a study utilizing doubly labeled 5-methyltetrahydrofolate and 5-formyltetrahydrofolate.
MedLine Citation:
PMID:  5314166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum disappearance curves in dogs after the intravenous injection of radioactive methotrexate, 5-methyltetrahydrofolate, 5-formyltetrahydrofolate, and folic acid followed first-order kinetics with half-disappearance times ranging from 1.3 to 9 hr respectively. Equilibration of spinal fluid tritium levels with those in serum was rapid (3.0 hr) for both of the reduced folates but was not observed at any time after folic acid and methotrexate. The only radioactive folate identified in the spinal fluid after intravenous injection of either 5-formyltetrahydrofolate or folic acid, as well as 5-methyltetrahydrofolate was 5-methyltetrahydrofolate. These findings indicated that 5-methyltetrahydrofolate was taken up preferentially into the spinal fluid and that the other folate congeners were converted to this compound before uptake. Diphenylhydantoin administration did not alter the uptake of 5-methyltetrahydrofolate into the spinal fluid but was associated with reduced renal excretion of this compound.
Authors:
M Levitt; P F Nixon; J H Pincus; J R Bertino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  50     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1971 Jun 
Date Detail:
Created Date:  1971-07-15     Completed Date:  1971-07-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1301-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Anemia, Macrocytic / drug therapy
Animals
Biological Transport
Blood-Brain Barrier
Carbon Isotopes
Chromatography, Gel
Dogs
Female
Folic Acid / blood,  cerebrospinal fluid*,  metabolism*
Kinetics
Leucovorin / cerebrospinal fluid*,  metabolism*
Male
Phenytoin / pharmacology
Tritium
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 10028-17-8/Tritium; 57-41-0/Phenytoin; 58-05-9/Leucovorin; 59-30-3/Folic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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