Document Detail

Transport characteristics of folates in cerebrospinal fluid; a study utilizing doubly labeled 5-methyltetrahydrofolate and 5-formyltetrahydrofolate.
MedLine Citation:
PMID:  5314166     Owner:  NLM     Status:  MEDLINE    
Serum disappearance curves in dogs after the intravenous injection of radioactive methotrexate, 5-methyltetrahydrofolate, 5-formyltetrahydrofolate, and folic acid followed first-order kinetics with half-disappearance times ranging from 1.3 to 9 hr respectively. Equilibration of spinal fluid tritium levels with those in serum was rapid (3.0 hr) for both of the reduced folates but was not observed at any time after folic acid and methotrexate. The only radioactive folate identified in the spinal fluid after intravenous injection of either 5-formyltetrahydrofolate or folic acid, as well as 5-methyltetrahydrofolate was 5-methyltetrahydrofolate. These findings indicated that 5-methyltetrahydrofolate was taken up preferentially into the spinal fluid and that the other folate congeners were converted to this compound before uptake. Diphenylhydantoin administration did not alter the uptake of 5-methyltetrahydrofolate into the spinal fluid but was associated with reduced renal excretion of this compound.
M Levitt; P F Nixon; J H Pincus; J R Bertino
Related Documents :
10413336 - Awareness of folic acid for neural tube defect prevention among israeli women.
11535566 - Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate...
15016776 - Endothelial function in post-menopausal women: effect of folic acid supplementation.
2500406 - Folinic acid modulation of fluorouracil: tissue kinetics of bolus administration.
20099896 - Benzotetramisole-catalyzed dynamic kinetic resolution of azlactones.
10794666 - Monocarboxylic acid transporters, mct1 and mct2, in cortical astrocytes in vitro and in...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  50     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1971 Jun 
Date Detail:
Created Date:  1971-07-15     Completed Date:  1971-07-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1301-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anemia, Macrocytic / drug therapy
Biological Transport
Blood-Brain Barrier
Carbon Isotopes
Chromatography, Gel
Folic Acid / blood,  cerebrospinal fluid*,  metabolism*
Leucovorin / cerebrospinal fluid*,  metabolism*
Phenytoin / pharmacology
Reg. No./Substance:
0/Carbon Isotopes; 10028-17-8/Tritium; 57-41-0/Phenytoin; 58-05-9/Leucovorin; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Abdominal aortic aneurysmectomy, 1968-1969. A review of recent experience of the Southern California...
Next Document:  Medical presentations of choriocarcinoma.