Document Detail


Transport of amino acids by the human placenta: predicted effects thereon of maternal hyperphenylalaninaemia.
MedLine Citation:
PMID:  2122124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brush border and basal plasma membrane vesicles prepared from normal term human placental syncytiotrophoblast have been used to study amino acid transport. Such studies are reviewed and novel results presented which confirm that saturation of placental transport by phenylalanine is unlikely to limit delivery of this amino acid to the fetus even with grossly raised maternal concentrations. Such raised maternal levels of phenylalanine are, however, likely to severely embarrass the delivery to the fetus across the placental brush border membrane of L-tyrosine and, to a lesser extent, of L-tryptophan. Reasons for thinking that this may be relevant to the fetal damage found in maternal PKU are discussed.
Authors:
Y Kudo; C A Boyd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of inherited metabolic disease     Volume:  13     ISSN:  0141-8955     ISO Abbreviation:  J. Inherit. Metab. Dis.     Publication Date:  1990  
Date Detail:
Created Date:  1990-12-07     Completed Date:  1990-12-07     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  7910918     Medline TA:  J Inherit Metab Dis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  617-26     Citation Subset:  IM    
Affiliation:
Department of Human Anatomy, Oxford University, UK.
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Maternal-Fetal Exchange*
Microvilli / metabolism
Phenylalanine / metabolism*
Phenylketonurias / metabolism*
Placenta / metabolism*
Pregnancy
Chemical
Reg. No./Substance:
63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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