Document Detail


Transplanted human amniotic epithelial cells secrete paracrine pro-angiogenic cytokines in rat model of myocardial infarction.
MedLine Citation:
PMID:  25420194     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Human amniotic epithelial cells (h-AECs) have been shown to differentiate into cardiomyocyte-like cells in vivo that can regenerate myocardial tissue and improve cardiac function in a rat model of myocardial infarction (MI). In this study, we investigated the paracrine factors released from h-AECs under hypoxic conditions to elucidate the possible mechanisms underlying this previously reported phenomenon of h-AEC-mediated cardiac repair. We used hypoxic cell culture conditions to simulate myocardial infarction in vitro. In comparison to normal conditions, we found that h-AECs secreted higher levels of several cytokines, including angiogenin (ANG), epidermal growth factor (EGF), interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1. To determine whether transplanted h-AECs express these pro-angiogenic cytokines in vivo, we ligated the coronary artery of rats to cause MI and injected either h-AECs or saline into the infarcted area. We found that the infarct and border zones of rat myocardium treated with h-AECs had higher expression levels of the human-origin cytokines ANG, EGF, IL-6, and MCP-1 compared the tissues of saline-treated rats. In conclusion, h-AECs secreted pro-angiogenic cytokines in a rat model of MI, which may suggest that the paracrine effect by h-AEC could regenerate myocardium tissue and improve cardiac function.
Authors:
Yi-Sun Song; Hyun-Woo Joo; In-Hwa Park; Guang-Yin Shen; Yonggu Lee; Jeong Hun Shin; Hyuck Kim; Il-Seob Shin; Kyung-Soo Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-21
Journal Detail:
Title:  Cell transplantation     Volume:  -     ISSN:  1555-3892     ISO Abbreviation:  Cell Transplant     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-24     Completed Date:  -     Revised Date:  2014-11-25    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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