| Transplantation or removal of intra-abdominal adipose tissue prevents age-induced glucose insensitivity. | |
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MedLine Citation:
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PMID: 20570685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increases in intra-abdominal fat, a common feature associated with aging, is an established risk factor for insulin resistance, diabetes and the metabolic syndrome. To examine the direct contribution of intra-abdominal fat in the pathophysiology of insulin resistance we altered fat volume via removal or transplantation in a naturally occurring age-induced moderate model of obesity and insulin resistance. This was accomplished by bilateral removal of epididymal white adipose tissue (Lipx) or transplantation of donor fat into the intra-abdominal side of the peritoneal cavity of 28-week old rats. Control animals received sham surgery. Glucose tolerance was evaluated at baseline and 4 and 8weeks post-surgery in all groups, and fasting insulin and leptin were additionally measured in 28-week old rats. In addition, fasted and fed triglyceride, cholesterol and fatty acid concentrations were measured. Before surgery 28-week old rats weighed more and were glucose intolerant compared with 8-week old controls. Both Lipx and transplantation significantly prevented age-induced decreases in glucose tolerance, with Lipx causing improvement at 4weeks which declined by 8weeks; and with a significant transplantation improvement at 8weeks only. Lipx significantly increased insulin secretion 15min after a bolus injection of 0.75mg/kg dextrose at 4 and 8weeks compared with controls, while transplantation caused a significant ( approximately 220%) increase in fasted leptin level at 4weeks only. Taken together, these data suggest that surgical removal or addition of intra-abdominal fat prevents age-induced insulin resistance by different mechanisms and is a suitable model to investigate naturally occurring obesity. |
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Authors:
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Michelle T Foster; Haifei Shi; Randy J Seeley; Stephen C Woods |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-06-04 |
Journal Detail:
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Title: Physiology & behavior Volume: 101 ISSN: 1873-507X ISO Abbreviation: Physiol. Behav. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-11-15 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 282-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Obesity Research Center, Department of Psychiatry, University of Cincinnati, 2170 E. Galbraith Road, Cincinnati, OH 45237, United States. Michelle.Foster@uc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aging* Analysis of Variance Animals Body Mass Index Glucose / pharmacology Glucose Tolerance Test / methods Insulin / blood Insulin Resistance / physiology* Intra-Abdominal Fat / metabolism*, pathology, transplantation Leptin / blood Lipid Metabolism / drug effects Male Rats Rats, Long-Evans Time Factors Tissue Transplantation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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K01 DK087816-01/DK/NIDDK NIH HHS; P01 DK056863-10/DK/NIDDK NIH HHS; R01 DK017844-35/DK/NIDDK NIH HHS; R01 DK054890-11/DK/NIDDK NIH HHS; R01 DK073505-05/DK/NIDDK NIH HHS; R01 DK078201-04/DK/NIDDK NIH HHS; T32 DK059803-09/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 11061-68-0/Insulin; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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