Document Detail

Transplantation for primary biliary cirrhosis.
MedLine Citation:
PMID:  9170201     Owner:  NLM     Status:  MEDLINE    
Primary biliary cirrhosis (PBC) remains one of the commoner indications for orthotopic liver replacement. The two main indications for transplantation are poor quality of life (because of the liver) or end-stage liver disease. A number of prognostic models have identified risk factors indicating poor prognosis, but in practice serum bilirubin greater than 150 mumol/L is used most commonly. Other indications for transplantation include progression of hepatopulmonary syndrome, increasing osteoporosis, evidence of malnutrition, and development of hepatocellular carcinoma. Postoperatively, patients do well. Recurrence of PBC remains controversial, but an increasing number of centers now report that a proportion of patients develop evidence of recurrent disease in the allograft. As yet PBC recurrence remains of little practical importance, although as survival increases beyond 10 years, this may become more relevant.
J Neuberger
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in liver disease     Volume:  17     ISSN:  0272-8087     ISO Abbreviation:  Semin. Liver Dis.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-08-25     Completed Date:  1997-08-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8110297     Medline TA:  Semin Liver Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-46     Citation Subset:  IM    
Queen Elizabeth Hospital, Edgbaston, Birmingham, England.
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MeSH Terms
Fatigue / etiology
Liver Cirrhosis, Biliary / complications,  mortality,  therapy*
Liver Transplantation*
Patient Selection
Predictive Value of Tests
Pruritus / etiology
Quality of Life
Survival Rate
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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