Document Detail


TRANSPLANTATION IMMUNITY OF GESTATIONAL ORIGIN IN INFANT RATS.
MedLine Citation:
PMID:  14237209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Comparison of the survival times of homografts of BN skin on 3-day-old Lewis rats born of mothers of the same isogenic strain with those of BN grafts on infant Lewis hosts that had developed in an F(1) (Lewis x BN) hybrid, gave no evidence of maternally induced tolerance as a result of development in an antigenically alien environment. On the contrary, the significantly shorter median survival time of the grafts on the hybrid-derived Lewis group suggests that sensitization had occurred as a consequence of natural exposure during gestation to small numbers of maternal cells.
Authors:
R E BILLINGHAM; J PALM; W K SILVERS
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  147     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1965 Jan 
Date Detail:
Created Date:  1965-04-01     Completed Date:  1996-12-01     Revised Date:  2011-11-30    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  514-6     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Animals, Newborn*
Immune Tolerance*
Maternal-Fetal Exchange*
Pregnancy*
Pregnancy, Animal*
Rats*
Research*
Skin Transplantation*
Transplantation Immunology*
Transplantation, Homologous*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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