| Transplantation of human adipose tissue-derived multilineage progenitor cells reduces serum cholesterol in hyperlipidemic Watanabe rabbits. | |
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MedLine Citation:
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PMID: 20698754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Familial hypercholesterolemia (FH) is an autosomal codominant disease characterized by high concentrations of proatherogenic lipoproteins and premature atherosclerosis secondary to low-density lipoprotein (LDL) receptor deficiency. We examined a novel cell therapy strategy for the treatment of FH in the Watanabe heritable hyperlipidemic (WHHL) rabbit, an animal model for homozygous FH. We delivered human adipose tissue-derived multilineage progenitor cells (hADMPCs) via portal vein and followed by immunosuppressive regimen to avoid xenogenic rejection. Transplantation of hADMPCs resulted in significant reductions in total cholesterol, and the reductions were observed within 4 weeks and maintained for 12 weeks. (125)I-LDL turnover study showed that the rate of LDL clearance was significantly higher in the WHHL rabbits with transplanted hADMPCs than those without transplanted. After transplantation hADMPCs were localized in the portal triad, subsequently integrated into the hepatic parenchyma. The integrated cells expressed human albumin, human alpha-1-antitrypsin, human Factor IX, human LDL receptors, and human bile salt export pump, indicating that the transplanted hADMPCs resided, survived, and showed hepatocytic differentiation in vivo and lowered serum cholesterol in the WHHL rabbits. These results suggested that hADMPC transplantation could correct the metabolic defects and be a novel therapy for inherited liver diseases. |
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Authors:
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Hanayuki Okura; Ayami Saga; Yuichi Fumimoto; Mayumi Soeda; Mariko Moriyama; Hiroyuki Moriyama; Koji Nagai; Chun-Man Lee; Shizuya Yamashita; Akihiro Ichinose; Takao Hayakawa; Akifumi Matsuyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-26 |
Journal Detail:
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Title: Tissue engineering. Part C, Methods Volume: 17 ISSN: 1937-3392 ISO Abbreviation: Tissue Eng Part C Methods Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: 2011-06-10 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 101466663 Medline TA: Tissue Eng Part C Methods Country: United States |
Other Details:
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Languages: eng Pagination: 145-54 Citation Subset: IM |
Affiliation:
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Department of Somatic Stem Cell Therapy and Health Policy, Foundation for Biomedical Research and Innovation, Kobe, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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cytology* Adult Animals Biological Markers / metabolism Cell Differentiation Cell Lineage* Cell Shape Cell Survival Cholesterol / blood* Female Hepatocytes / cytology Humans Hyperlipidemias / blood* Immunohistochemistry Immunosuppression Male Middle Aged Rabbits Stem Cell Transplantation* Stem Cells / cytology*, metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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