| Transplantation of fetal dopamine neurons in Parkinson's disease: PET [18F]6-L-fluorodopa studies in two patients with putaminal implants. | |
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MedLine Citation:
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PMID: 1575455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two patients with Parkinson's disease who underwent implantation of fetal mesencephalic tissue into the putamen were serially studied using positron emission tomography and [18F]6-L-fluorodopa ([18F]dopa). The uptake of [18F]dopa is related to the functional integrity of the presynaptic dopaminergic system. Preoperative studies revealed a marked decrease in putamen [18F]dopa uptake, with lesser involvement of the caudate. Two and 4 months, respectively, after operation, both patients demonstrated functional improvement, as described elsewhere. One patient was scanned 5, 8, and 13 months after the operation and the other was scanned 7 and 12 months after the operation. In both patients, [18F]dopa uptake increased within the operated putamen despite a progressive decrease in tracer uptake in the unoperated striatal structures. We believe that this increased uptake of [18F]dopa at the implantation site represents functional integrity within a surviving neural graft. While there has been little further clinical improvement beyond the fifth postoperative month, the uptake of [18F]dopa at the operation site in both patients has progressively increased. The kinetic data provide evidence of disease progression in the unoperated striatum, which, balanced against increasing graft function, may explain why clinical improvement reached a plateau within months after surgery. |
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Authors:
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G V Sawle; P M Bloomfield; A Björklund; D J Brooks; P Brundin; K L Leenders; O Lindvall; C D Marsden; S Rehncrona; H Widner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 31 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-06-01 Completed Date: 1992-06-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 166-73 Citation Subset: IM |
Affiliation:
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Medical Research Council Cyclotron Unit, Hammersmith Hospital, London, England. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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adverse effects Brain Tissue Transplantation* Caudate Nucleus / radionuclide imaging Dihydroxyphenylalanine / analogs & derivatives*, diagnostic use, pharmacokinetics Dopamine / metabolism* Fetal Tissue Transplantation* Humans Mesencephalon / embryology, transplantation* Models, Biological Parkinson Disease / radionuclide imaging, surgery* Parkinson Disease, Secondary / radionuclide imaging, surgery Putamen / radionuclide imaging, surgery* Tomography, Emission-Computed* |
| Chemical | |
Reg. No./Substance:
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28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 42877-15-6/5-fluorodopa; 63-84-3/Dihydroxyphenylalanine |
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