Document Detail


Transplantation of allogenic fetal membrane-derived mesenchymal stem cells protect against ischemia-reperfusion-induced acute kidney injury.
MedLine Citation:
PMID:  23562186     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mesenchymal stem cells (MSCs) are an attractive therapeutic cell source fortreating renal diseases. MSCs administration has been shown to improve renalfunction, although underlying mechanisms are incompletely understood. We recentlyshowed that allogenic fetal membrane-derived MSCs (FM-MSCs), which are availablenon-invasively in large amounts, had renoprotective effect in an experimentalglomerulonephritis model. Here, we investigated whether allogenic FM-MSCsadministration could protect kidneys from ischemia/reperfusion (I/R) injury.Lewis rats were subjected to right nephrectomy and left renal I/R injury byclamping left renal artery as acute kidney injury (AKI) model. After declamping FMMSCs(5x105 cells) obtained from major histocompatibility complex (MHC) mismatched-ACI rats were intravenously administered.I/R injured rats exhibited increased serum creatinine and BUN, whereas FMMSCsadministration significantly ameliorated renal function. Histological analysisrevealed that FM-MSCs administration significantly suppressed tubular apoptosis andinfiltration of macrophages and T cells. Administration of FM-MSCs mainly homed intolung, but increased serum IL-10 levels. Of interest is that renoprotective effects of FMMSCswere abolished by using anti-IL-10 neutralization antibody, suggesting that IL-10 would be one of the candidate factors to protect rat kidney from I/R injury in thismodel. We concluded that allogenic FM-MSCs transplantation is a potent therapeuticstrategy for the treatment of AKI.
Authors:
Hidetoshi Tsuda; Kenichi Yamahara; Kentaro Otani; Masayoshi Okumi; Koji Yazawa; Jun Ya Kaimori; Akihiko Taguchi; Kenji Kangawa; Tomoaki Ikeda; Shiro Takahara; Yoshitaka Isaka
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-2
Journal Detail:
Title:  Cell transplantation     Volume:  -     ISSN:  1555-3892     ISO Abbreviation:  Cell Transplant     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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