Document Detail


Transplantation of CD34+ selected peripheral blood to HLA-identical sibling patients with aplastic anaemia: results from a single institution.
MedLine Citation:
PMID:  15968276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the use of CD34+ selected allogeneic peripheral blood as a source of hematopoietic progenitors for allogeneic transplantation in 11 patients with aplastic anemia (AA). The median age was 17 years (range, 6--9), and the median time between diagnosis and transplant 1 month (range, 1--4). Conditioning consisted of cyclophosphamide (50 mg/kg per day) on days--7 to--4 and antithymocyte globulin (30 mg/kg per day) on days--4 to--2 in nine patients. Total lymphoid irradiation was added to the preparative regimen for two. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine A and prednisone. Median doses of CD34+ and CD3+ cells infused were 3.91 x 10(6) and 0.3 x 10(6)/kg, respectively. The median time taken to achieve a neutrophil count >0.5 x 10(9)/l was 12 days and to recover a platelet count >20 x 10(9)/l, 13 days. Two patients developed acute GVHD grade I--II and one developed limited chronic GVHD. There were two treatment-related deaths. At a median follow-up of 44 months (range, 4--3), nine patients were alive with sustained and complete engraftment. This is a promising procedure in patients with AA, resulting in a rapid hematopoietic recovery, a low transplant-related mortality, and a low incidence of GVHD.
Authors:
J de la Rubia; S Cantero; G F Sanz; M J Remigia; E Monteagudo; F Moscardó; G Martín; I Lorenzo; C Jiménez; J Martínez; P Montesinos; I Jarque; M A Sanz
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  36     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-01     Completed Date:  2005-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  325-9     Citation Subset:  IM    
Copyright Information:
Bone Marrow Transplantation (2005) 36, 325-329.
Affiliation:
Bone Marrow Transplant Unit, Hematology Service, University Hospital La Fe, Valencia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia, Aplastic / complications,  mortality,  therapy*
Antigens, CD3
Antigens, CD34*
Child
Graft Survival
Graft vs Host Disease / prevention & control
Histocompatibility Testing
Humans
Kinetics
Middle Aged
Peripheral Blood Stem Cell Transplantation / adverse effects,  methods*
Premedication
Radiotherapy, Adjuvant
Siblings
Survival Rate
Transplantation Conditioning / methods
Transplantation, Homologous
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antigens, CD3; 0/Antigens, CD34

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