Document Detail

Transplacental transport and tissue distribution of biotin in mice at midgestation.
MedLine Citation:
PMID:  18452485     Owner:  NLM     Status:  MEDLINE    
Biotin is a water-soluble vitamin which functions as a coenzyme of carboxylases in glucose and amino acid metabolism and fatty acid synthesis. Biotin is also essential for maintaining reproductive function. Biotin deficiency during gestation induces cleft palate, micrognathia and limb hypoplasia in mouse fetuses at near term. Maternal biotin deficiency is severely tetatogenic in mammals. However, the relationship between abnormal morphogenesis and biotin deficiency is not sufficiently clear. This study was conducted to elucidate the mechanism of biotin transport from dams to embryos and the nutritional roles of biotin in ICR mice. Pregnant mice were given either a biotin-deficient or biotin-supplemented diet, and biotin and biotinidase activity were determined in dams and fetuses. It became evident that biotin was supplied from dams to growing embryos during morphogenesis. In particular, a large amount of biotin was transported to palates and mandibles on days 12-15 of gestation. The transportation of biotin to fetuses differed among fetal growth periods and organs. These results suggest that biotin is an essential nutrient and may play an important role in embryonic growth.
Ayumi Taniguchi; Toshiaki Watanabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congenital anomalies     Volume:  48     ISSN:  0914-3505     ISO Abbreviation:  Congenit Anom (Kyoto)     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306292     Medline TA:  Congenit Anom (Kyoto)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Department of Dietary Environment Analysis, School of Human Science and Environment, Himeji Institute of Technology, University of Hyogo, Himeji, Japan.
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MeSH Terms
Biotin / pharmacokinetics*
Maternal-Fetal Exchange
Mice, Inbred ICR
Placenta / metabolism*
Reg. No./Substance:

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