| Transplacental transmission of HIV: a potential role for HIV binding lectins. | |
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MedLine Citation:
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PMID: 12531239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the majority of vertical transmission of HIV occurs around the time of birth, 1.5-2% of pregnancies in HIV-positive women appear to result in the vertical transmission of HIV across the placenta. HIV infection of a number of placental cell types has been demonstrated, but the exact mechanisms of intrauterine vertical transmission remain obscure. The recent discovery of the HIV binding lectins dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN) and DC-SIGN-related molecule (DC-SIGNR) provides one possible explanation. Cells expressing these lectins are able to adsorb the virus and mediate high efficiency HIV infection of other cell types. Both lectins are expressed by the placenta, with DC-SIGN expression also being present on maternal cells intimately associated with the placenta. This review focuses on possible mechanisms by which these lectins may potentiate the intrauterine vertical transmission of HIV. |
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Authors:
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Elizabeth J Soilleux; Nicholas Coleman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The international journal of biochemistry & cell biology Volume: 35 ISSN: 1357-2725 ISO Abbreviation: Int. J. Biochem. Cell Biol. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-01-17 Completed Date: 2003-10-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9508482 Medline TA: Int J Biochem Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 283-7 Citation Subset: IM |
Affiliation:
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Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 2XY, UK. ejs17@cam.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion Molecules / metabolism Female HIV-1 / metabolism* Humans Infectious Disease Transmission, Vertical* Lectins, C-Type / metabolism Models, Biological Placenta / virology* Plant Lectins / physiology* Pregnancy Pregnancy Complications, Infectious / prevention & control, virology Receptors, Cell Surface / metabolism |
| Chemical | |
Reg. No./Substance:
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0/CLEC4M protein, human; 0/Cell Adhesion Molecules; 0/DC-specific ICAM-3 grabbing nonintegrin; 0/Lectins, C-Type; 0/Plant Lectins; 0/Receptors, Cell Surface |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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