| Transplacental transfer of vancomycin and telavancin. | |
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MedLine Citation:
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PMID: 22867688 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: We sought to determine the bidirectional transfer and distribution of vancomycin and telavancin across the dually perfused term human placental lobule. STUDY DESIGN: The technique of dually perfused placental lobule was used in its recirculating mode to determine the maternal to fetal (M→F) (n = 20) and fetal to maternal (n = 18) transfer of each antibiotic, which were coperfused with their radioactive isotopes. The concentrations of drugs were determined by liquid scintillation spectrometry. RESULTS: In the M→F direction, the transfer of vancomycin (9.6 ± 4%) and telavancin (6.5 ± 2%) were low; however, telavancin retention by the perfused lobule was greater than that of vancomycin (P < .01). The normalized transplacental transfer of telavancin across the placental lobule in the fetal to maternal direction was higher than in the M→F direction (P < .01), suggesting the involvement of placental efflux transporters. CONCLUSION: The ex vivo perfusion experiments revealed low transfer of vancomycin and telavancin to the fetal circuit. |
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Authors:
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Tatiana Nanovskaya; Svetlana Patrikeeva; Ying Zhan; Valentina Fokina; Gary D V Hankins; Mahmoud S Ahmed |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-3 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: - ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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