Document Detail


Transplacental transfer of vancomycin and telavancin.
MedLine Citation:
PMID:  22867688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We sought to determine the bidirectional transfer and distribution of vancomycin and telavancin across the dually perfused term human placental lobule.
STUDY DESIGN: The technique of dually perfused placental lobule was used in its recirculating mode to determine the maternal to fetal (M→F) (n = 20) and fetal to maternal (n = 18) transfer of each antibiotic, which were coperfused with their radioactive isotopes. The concentrations of drugs were determined by liquid scintillation spectrometry.
RESULTS: In the M→F direction, the transfer of vancomycin (9.6 ± 4%) and telavancin (6.5 ± 2%) were low; however, telavancin retention by the perfused lobule was greater than that of vancomycin (P < .01). The normalized transplacental transfer of telavancin across the placental lobule in the fetal to maternal direction was higher than in the M→F direction (P < .01), suggesting the involvement of placental efflux transporters.
CONCLUSION: The ex vivo perfusion experiments revealed low transfer of vancomycin and telavancin to the fetal circuit.
Authors:
Tatiana Nanovskaya; Svetlana Patrikeeva; Ying Zhan; Valentina Fokina; Gary D V Hankins; Mahmoud S Ahmed
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-04
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2012-12-13     Revised Date:  2014-01-26    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  331.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aminoglycosides / pharmacokinetics*
Anti-Bacterial Agents / pharmacokinetics*
Female
Humans
Maternal-Fetal Exchange*
Perfusion
Placenta / drug effects,  metabolism*
Pregnancy
Vancomycin / pharmacokinetics*
Grant Support
ID/Acronym/Agency:
U10 HD047891/HD/NICHD NIH HHS; U10 HD047891/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 6Q205EH1VU/Vancomycin; XK134822Z0/telavancin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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