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Transplacental transfer of environmental genotoxins--polycyclic aromatic hydrocarbon-albumin in nonsmoking women.
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MedLine Citation:
PMID:  8781394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transplacental transfer of genotoxic material has been determined by measuring the polycyclic aromatic hydrocarbon-albumin adduct level in serum isolated from the mother and the umbilical cord blood using a competitive enzyme-linked immunoadsorbent assay (ELISA) and the antibody (8E11( against benzo[a]pyrene (B[a]P) tetrols. Smoking women (median = 5.54 fmol B[a]P eq/micrograms albumin; n = 21 cases) and nonsmoking women living in rural areas (median = 4.99; n = 30) had higher adduct levels than nonsmoking women living in suburbia (median = 4.09; n = 37), whereas nonsmoking women living in the city of Aarhus had an intermediate level (median = 4.82; n = 40). The median adduct level in umbilical cord blood was significantly lower than in maternal blood, the maternal/fetal ratio being approximately 1.3. A positive association between the adduct levels in the mother and umbilical cord blood was observed. This study indicates that the competitive ELISA to detect B[a]P bound to serum albumin is sensitive enough to detect differences in the burden of genotoxic compounds in nonoccupationally exposed individuals. The lower adduct level in people living in suburbia suggests that local production of incomplete combustion products, like vehicle exhaust or heat generation, is a contributing factor to genotoxic compounds in the general environment.
Authors:
H Autrup; A B Vestergaard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental health perspectives     Volume:  104 Suppl 3     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-03-19     Completed Date:  1997-03-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  625-7     Citation Subset:  IM    
Affiliation:
Department of Environmental and Occupational Medicine, University of Aarhus, Denmark. ha@mil.aau.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Carcinogens / metabolism*
Cohort Studies
Environmental Exposure
Female
Fetal Blood
Genotype
Glutathione Transferase / genetics
Humans
Maternal-Fetal Exchange*
Mutagens / metabolism*
Polycyclic Hydrocarbons, Aromatic / blood,  metabolism*
Pregnancy
Serum Albumin / analysis
Smoking / metabolism
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Mutagens; 0/Polycyclic Hydrocarbons, Aromatic; 0/Serum Albumin; EC 2.5.1.18/Glutathione Transferase
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 5 Year: 1996
Volume: 104 Issue: Suppl 3
First Page: 625 Last Page: 627
ID: 1469656
PubMed Id: 8781394

Transplacental transfer of environmental genotoxins--polycyclic aromatic hydrocarbon-albumin in nonsmoking women.
H Autrup
A B Vestergaard
Department of Environmental and Occupational Medicine, University of Aarhus, Denmark. ha@mil.aau.dk



Article Categories:
  • Research Article


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