Document Detail

Transplacental stimulation of functional and morphologic fetal rabbit lung maturation: effect of thyrotropin-releasing hormone.
MedLine Citation:
PMID:  3113253     Owner:  NLM     Status:  MEDLINE    
We investigated the effect of maternally administered thyrotropin-releasing hormone on functional and morphologic fetal lung maturation. Thyrotropin-releasing hormone (40 micrograms/kg/day) or the vehicle was injected intravenously into the New Zealand White rabbit does on days 25, 26, and 27 of gestation. On day 27 of pregnancy, the does were killed and the fetuses were delivered. The functional pulmonary maturity was assessed by pressure-volume hysteresis while morphologic maturity was assessed by histologic techniques. Enhanced functional and morphologic fetal lung maturation was noted in animals treated with thyrotropin-releasing hormone when compared with controls. An important role of thyrotropin-releasing hormone in fetal lung maturation is proposed.
U Devaskar; K Nitta; K Szewczyk; H F Sadiq; D deMello
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  157     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-09-23     Completed Date:  1987-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  460-4     Citation Subset:  AIM; IM    
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MeSH Terms
Fetal Organ Maturity / drug effects*
Lung / embryology*
Maternal-Fetal Exchange*
Thyrotropin-Releasing Hormone / pharmacology*
Reg. No./Substance:
24305-27-9/Thyrotropin-Releasing Hormone

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