Document Detail

Transplacental passage of antimicrobial paraben preservatives.
MedLine Citation:
PMID:  24770090     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Parabens are esters of p-hydroxybenzoic acid and are commonly used as preservatives in foods, cosmetics, pharmaceuticals, and personal care products. They are suspected endocrine disruptors and some have been found to bind estrogen receptors. Gestational exposure in animal studies has suggested a possible effect on later adult social behavior. The most common paraben is methyl-paraben, but butyl paraben and others are also used. To date, no study has examined whether these substances cross the human placenta.
METHODS: A total of 50 patients at two institutions were prospectively consented to participate in the study. A maternal blood sample was drawn on admission and a paired cord blood sample was obtained at delivery. Each sample was then analyzed for the presence of methyl-paraben and butyl paraben. Age, ethnicity, body mass index, and other demographics were gathered.
RESULTS: Of the 50 patients, 47 mothers (94%) were found to have methyl-paraben in their blood (mean level 20.41 ng/L) and 47 cord bloods (94%) contained methyl-paraben (mean level 36.54 ng/L). Although the fetal level was higher than the maternal level, this difference was not significant. Comparisons were made within different ethnic, age, and body mass index groups, but no differences were seen. For butyl paraben, only four mothers (8%) were positive, but there were eight total cord blood samples that were positive (16%).
CONCLUSIONS: Methyl and butyl parabens demonstrate transplacental passage and the fetal levels are often higher than the maternal values, although not significant.
Craig V Towers; Wesley Chambers; David Lewis; Bobby Howard; Jiangang Chen; Paul Terry
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  123 Suppl 1     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-04-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175S-6S     Citation Subset:  AIM; IM    
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