Document Detail

Transplacental needle passage and other risk-factors associated with second trimester amniocentesis.
MedLine Citation:
PMID:  9348248     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the obstetric outcome of all pregnancies undergoing midtrimester amniocentesis over a 10 year period at one center and the risk-factors for pregnancy loss associated to the procedure. MATERIAL AND METHOD: All 2083 pregnancies with known pregnancy outcome and second trimester amniocentesis were included. Risk-factors for pregnancy loss were analysed by using patients' charts and a special record from the amniocentesis. RESULTS: The over-all risk of pregnancy loss after second trimester amniocentesis was 1.3% (28/2083). There was a slight but nonsignificant relationship between the degree of experience of the gynecologist and risk for pregnancy loss. A more experienced operator used significantly fewer needle insertions (p<0.001). Multiple needle insertions were also associated with a slight, albeit nonsignificant, increase in incidence in fetal loss (3.8% after three or more insertions vs. 1.2% after one insertion, NS). No difference in spontaneous abortion incidence was found in patients having an anterior versus a posterior placenta, nor did transplacental needle passage increase the risk for pregnancy loss. Comparison between use of real-time ultrasonic guidance at the amniocentesis and static ultrasonography immediately prior to the procedure did not reveal any differences in the incidence in spontaneous abortion. CONCLUSION: Second trimester amniocentesis seems to be a safe method for prenatal diagnosis. The risk for pregnancy loss was low (1.3%) and was only slightly and nonsignificantly affected by the operator's experience and multiple needle insertions. Transplacental needle passage did not affect the risk of pregnancy loss.
T Marthin; S Liedgren; M Hammar
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  76     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-06     Completed Date:  1997-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  728-32     Citation Subset:  IM    
Department of Obstetrics & Gynaecology, Faculty of Health Sciences, University Hospital of Linköping, Sweden.
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MeSH Terms
Abortion, Spontaneous / prevention & control
Amniocentesis / adverse effects*
Pregnancy Outcome
Pregnancy Trimester, Second
Prenatal Diagnosis / methods*
Risk Factors
Ultrasonography, Prenatal*

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