Document Detail

Transplacental infection of Coxsackievirus B3 pathological findings in the fetus.
MedLine Citation:
PMID:  17457913     Owner:  NLM     Status:  MEDLINE    
Coxsackievirus intrauterine infection has been documented mostly on the basis of indirect evidence of transplacental transmission, with neonatal manifestations ranging from asymptomatic infection to meningoencephalitis, myocarditis, and generalized sepsis. This is the first report of prenatal findings and fetoplacental pathology in a third trimester fetus with coxsackie B3 transplacental infection confirmed by molecular techniques. Prenatal ultrasound detected severe reduction of fetal movements at the 27th week. Late onset fetal akinesia deformation sequence with mild arthrogryposis, necrotic meningoencephalitis with vascular calcifications, interstitial pneumonitis, mild myocardial hypertrophy, and chronic monocytic placental villitis were the cardinal findings at fetal autopsy following interruption of the pregnancy.
Anastasia Konstantinidou; Hector Anninos; Nikolaos Spanakis; Xenophon Kotsiakis; Garyfallia Syridou; Athanassios Tsakris; Efstratios Patsouris
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  79     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-07-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  754-7     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Department of Pathology, Medical School, National Kapodistrian University of Athens, Athens, Greece.
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MeSH Terms
Abortion, Induced
Arthrogryposis / pathology
Base Sequence
Blood Vessels / pathology
Calcinosis / pathology
Cardiomegaly / pathology
Chorionic Villi / pathology
Coxsackievirus Infections / pathology*,  transmission*,  virology
Enterovirus B, Human / genetics,  isolation & purification*
Fetal Diseases / pathology*
Fetal Movement
Fetus / pathology*
Infectious Disease Transmission, Vertical*
Leukoencephalitis, Acute Hemorrhagic / pathology
Lung Diseases, Interstitial / pathology
Molecular Sequence Data
Placenta Diseases / pathology
Pregnancy Complications, Infectious
Sequence Alignment
Ultrasonography, Prenatal

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