Document Detail

Transplacental induction of lymphomas in Swiss mice by carbendazim and sodium nitrite.
MedLine Citation:
PMID:  988851     Owner:  NLM     Status:  MEDLINE    
Swiss mice at different stages of pregnancy were treated intragastrically with the pesticide Carbendazim (MBC, BCM, methyl-2-benzimidazole carbamate) together with sodium nitrite. Lymphomas developed in 33.3% of young mice whose mothers were treated in the first week of pregnancy, in 53.3% of whose mothers were treated during the second week, and in 38.8% of those born of mothers treated during the third week. Treatment during the whole period of pregnancy yielded on an average 70.0% malignancy in offspring. However, administration of Carbendazim by itself did not produce lymphomas in the first generation. In lymphomas induced by in vivo-formed n-nitroso compounds, A- and C-type oncornavirus particles were observed with the electron microscope.
M Börzsönyi; A Pintér; A Surján; I Farkas
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  17     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-10-01     Completed Date:  1976-10-01     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  742-7     Citation Subset:  IM    
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MeSH Terms
Benzimidazoles* / administration & dosage
Carbamates / administration & dosage
Cytoplasm / ultrastructure
Dose-Response Relationship, Drug
Fungicides, Industrial / administration & dosage
Gestational Age
Lymphocytes / ultrastructure
Lymphoma, Non-Hodgkin / chemically induced*,  pathology
Maternal-Fetal Exchange*
Neoplasms, Experimental / chemically induced
Nitrites* / administration & dosage
Reg. No./Substance:
0/Benzimidazoles; 0/Carbamates; 0/Carcinogens; 0/Fungicides, Industrial; 0/Nitrites

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