Document Detail

Transplacental effects of 3,5-dimethyl-3'-isopropyl-L-thyronine on tubulin content in fetal brains in rats.
MedLine Citation:
PMID:  6471617     Owner:  NLM     Status:  MEDLINE    
When 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) (10 ng/(g X day] was administered to pregnant rats, their infants showed signs of hyperthyroidism with suppressed body weight, tachycardia, and tremor at the day of birth. The brain weight did not change but the wet weight of the cerebral cortex was increased in the infants. Tubulin content (per wet weight and per whole tissue) was increased in the cerebral cortex and cerebellum but remained unchanged in the hypothalamus in the DIMIT-treated group. DIMIT-induced hyperthyroidism was shown to affect the development of the fetal brain.
T Takahashi
Related Documents :
8335017 - Isolation of adenovirus type 11 from the brain of a neonate with pneumonia and encephal...
7766967 - Mri characterization of cerebral dysgenesis in maternal pku.
16770667 - Brain ultrasonography in the premature infant.
11978747 - Magnetic resonance imaging of the infant brain: anatomical characteristics and clinical...
11520627 - Home oxygen therapy in infants with bronchopulmonary dysplasia: assessment of parental ...
18310187 - Cord blood and breast milk iron status in maternal anemia.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  34     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-15     Completed Date:  1984-10-15     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  365-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / embryology,  metabolism*
Hyperthyroidism / chemically induced,  embryology
Maternal-Fetal Exchange*
Prenatal Exposure Delayed Effects
Rats, Inbred Strains
Thyronines / pharmacology*
Tissue Distribution
Tubulin / metabolism*
Reg. No./Substance:
0/Thyronines; 0/Tubulin; 26384-44-1/3,5-dimethyl-3'-isopropyl-L-thyronine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Arsenazo III signals following action potential as influenced by nitrate in Xenopus skeletal muscle.
Next Document:  Antidiuretic effects of oxotremorine microinjected into the hypothalamic supraoptic and paraventricu...