Document Detail

Transplacental effects of 3,5-dimethyl-3'-isopropyl-L-thyronine on tubulin content in fetal brains in rats.
MedLine Citation:
PMID:  6471617     Owner:  NLM     Status:  MEDLINE    
When 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) (10 ng/(g X day] was administered to pregnant rats, their infants showed signs of hyperthyroidism with suppressed body weight, tachycardia, and tremor at the day of birth. The brain weight did not change but the wet weight of the cerebral cortex was increased in the infants. Tubulin content (per wet weight and per whole tissue) was increased in the cerebral cortex and cerebellum but remained unchanged in the hypothalamus in the DIMIT-treated group. DIMIT-induced hyperthyroidism was shown to affect the development of the fetal brain.
T Takahashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  34     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-15     Completed Date:  1984-10-15     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  365-8     Citation Subset:  IM    
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MeSH Terms
Brain / embryology,  metabolism*
Hyperthyroidism / chemically induced,  embryology
Maternal-Fetal Exchange*
Prenatal Exposure Delayed Effects
Rats, Inbred Strains
Thyronines / pharmacology*
Tissue Distribution
Tubulin / metabolism*
Reg. No./Substance:
0/Thyronines; 0/Tubulin; 26384-44-1/3,5-dimethyl-3'-isopropyl-L-thyronine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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