Document Detail

Transplacental effects of a 15% olive-oil diet on chemically-induced tumorigenesis in offspring.
MedLine Citation:
PMID:  10948354     Owner:  NLM     Status:  MEDLINE    
We evaluated whether feeding pregnant female rats a diet high in olive-oil, that showed a tumor-preventive effect in adults, has a similar preventive effect on chemically-induced cancer in offspring (i.e. mammary glands and colon cancer in rats). The control group was fed the same 7% corn-oil diet as their mothers. Experimental group I was fed a 7% corn-oil diet while their mothers received a 15% olive-oil diet. Experimental group II was fed the same 15% olive-oil diet as their mothers. Female offspring were twice administered 7,12-dimethylbenz(a)antracene (DMBA) in doses of 10 mg/rat. Male offspring were injected 6 times with 1, 2-dimethylhydrazine (DMH) in doses of 20 mg/kg body weight. Effect of DMBA was manifested in a high rate of tumorigenesis: the number of tumor-bearing rats in control offspring reached 52.0%. This effect increased to 60.6% among offspring of experimental group II and to 67.7% in offspring of experimental group I. The mean tumor size increased significantly in control offspring. Following administration of DMH number of tumor-bearing rats was similar in all groups of offspring: 36.7%, 40.7% and 42.8%. Tumor types differed: the majority of tumors in the control group were benign polyps and adenomas (72.1%) and the number of adenocarcinomas was low (27.9%). The number of malignant tumors increased to 37.5% in offspring of experimental group II and to 45.5% in offspring of experimental group I. In control group offspring, a distinct tendency to increased body weight and a significant increase in spleen weight were seen. The findings indicate that feeding mothers a diet high in fat concentrations, even those with known tumor preventive significance in adults, lose this cancer-inhibiting role in offspring.
G Kossoy; G Yarden; H Benhur; B Sandler; I I Zusman; A Stark; Z Madar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology reports     Volume:  7     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:    2000 Sep-Oct
Date Detail:
Created Date:  2000-08-24     Completed Date:  2001-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1145-8     Citation Subset:  IM    
Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
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MeSH Terms
Anticarcinogenic Agents / administration & dosage*
Colonic Neoplasms / chemically induced,  diet therapy,  prevention & control*
Mammary Neoplasms, Experimental / chemically induced,  diet therapy,  prevention & control*
Maternal-Fetal Exchange / physiology*
Plant Oils / administration & dosage*
Prenatal Exposure Delayed Effects*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Carcinogens; 0/Plant Oils; 540-73-8/1,2-Dimethylhydrazine; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 8001-25-0/olive oil

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