| Transplacental effects of a 15% olive-oil diet on chemically-induced tumorigenesis in offspring. | |
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MedLine Citation:
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PMID: 10948354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated whether feeding pregnant female rats a diet high in olive-oil, that showed a tumor-preventive effect in adults, has a similar preventive effect on chemically-induced cancer in offspring (i.e. mammary glands and colon cancer in rats). The control group was fed the same 7% corn-oil diet as their mothers. Experimental group I was fed a 7% corn-oil diet while their mothers received a 15% olive-oil diet. Experimental group II was fed the same 15% olive-oil diet as their mothers. Female offspring were twice administered 7,12-dimethylbenz(a)antracene (DMBA) in doses of 10 mg/rat. Male offspring were injected 6 times with 1, 2-dimethylhydrazine (DMH) in doses of 20 mg/kg body weight. Effect of DMBA was manifested in a high rate of tumorigenesis: the number of tumor-bearing rats in control offspring reached 52.0%. This effect increased to 60.6% among offspring of experimental group II and to 67.7% in offspring of experimental group I. The mean tumor size increased significantly in control offspring. Following administration of DMH number of tumor-bearing rats was similar in all groups of offspring: 36.7%, 40.7% and 42.8%. Tumor types differed: the majority of tumors in the control group were benign polyps and adenomas (72.1%) and the number of adenocarcinomas was low (27.9%). The number of malignant tumors increased to 37.5% in offspring of experimental group II and to 45.5% in offspring of experimental group I. In control group offspring, a distinct tendency to increased body weight and a significant increase in spleen weight were seen. The findings indicate that feeding mothers a diet high in fat concentrations, even those with known tumor preventive significance in adults, lose this cancer-inhibiting role in offspring. |
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Authors:
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G Kossoy; G Yarden; H Benhur; B Sandler; I I Zusman; A Stark; Z Madar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Oncology reports Volume: 7 ISSN: 1021-335X ISO Abbreviation: Oncol. Rep. Publication Date: 2000 Sep-Oct |
Date Detail:
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Created Date: 2000-08-24 Completed Date: 2001-01-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: GREECE |
Other Details:
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Languages: eng Pagination: 1145-8 Citation Subset: IM |
Affiliation:
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Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1,2-Dimethylhydrazine 9,10-Dimethyl-1,2-benzanthracene Animals Anticarcinogenic Agents / administration & dosage* Carcinogens Colonic Neoplasms / chemically induced, diet therapy, prevention & control* Diet Female Male Mammary Neoplasms, Experimental / chemically induced, diet therapy, prevention & control* Maternal-Fetal Exchange / physiology* Plant Oils / administration & dosage* Pregnancy Prenatal Exposure Delayed Effects* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Carcinogens; 0/Plant Oils; 540-73-8/1,2-Dimethylhydrazine; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 8001-25-0/olive oil |
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