Document Detail


Transplacental transfer of oseltamivir carboxylate.
MedLine Citation:
PMID:  22590979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Determine the bidirectional transfer of oseltamivir carboxylate (OC) across term human placenta and its distribution between the tissue, maternal and fetal circuits.
METHODS: The technique of dual perfusion of placental lobule (DPPL) in its recirculating mode was utilized to determine the transfer of the drug. OC (350 ng/mL) was co-perfused with its [(3)H]-isotope and the marker compound antipyrine (AP, 20 µg/mL) together with its [(14)C]-isotope. The concentrations of OC and any of its metabolite(s) formed during perfusion were determined in the tissue, maternal and fetal circuits by liquid scintillation spectrometry following their separation by High Performance Liquid Chromatography (HPLC).
RESULTS: The distribution of OC following its perfusion in the Maternal-to-Fetal direction for 4 h was as follows: 21 ± 4% of the drug was transferred to the fetal circuit, 13 ± 5% was retained by the perfused lobule, and 66 ± 4% remained in the maternal circuit. The normalized transfer of OC to that of AP (Clearance index) in the maternal-to-fetal direction was (0.47 ± 0.11) and was not different from its transfer from the fetal-to-maternal direction (0.47 ± 0.06) suggesting that involvement of placental efflux transporters is unlikely.
CONCLUSIONS: OC crosses human placenta. As the transfer rate of OC is 47% of the freely diffusible AP, it is likely that fetus could be exposed to OC during pregnancy.
Authors:
Tatiana N Nanovskaya; Svetlana Patrikeeva; Ying Zhan; Gary D V Hankins; Mahmoud S Ahmed
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-07
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-15     Completed Date:  2013-04-30     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  2312-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / pharmacokinetics
Biological Transport / physiology
Cells, Cultured
Diffusion
Female
Humans
Maternal-Fetal Exchange / physiology
Organ Culture Techniques
Oseltamivir / analogs & derivatives*,  pharmacokinetics
Perfusion
Placenta / metabolism*
Pregnancy
Term Birth / metabolism
Tissue Distribution
Grant Support
ID/Acronym/Agency:
U10 HD047891/HD/NICHD NIH HHS; U10-HD 047891/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/oseltamivir carboxylate; 20O93L6F9H/Oseltamivir
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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